六亚甲基三过氧化二胺的代谢以及过氧化物炸药（三过氧化三丙酮和六亚甲基三过氧化二胺）在犬类和人类体内的血液稳定性与毒性
metabolism of HMTD and blood stability and toxicity of peroxide explosives (TATP and HMTD) in canines and humans.
作者信息
Gonsalves Michelle D, McLennan Lindsay, Slitt Angela L, Smith James L, Oxley Jimmie C
机构信息
Department of Chemistry, University of Rhode Island, Kingston, RI, USA.
Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA.
出版信息
Xenobiotica. 2021 Apr;51(4):394-403. doi: 10.1080/00498254.2021.1874563. Epub 2021 Jan 20.
Triacetone triperoxide (TATP) and hexamethylene triperoxide diamine (HMTD) are prominent explosive threats. Mitigation of peroxide explosives is a priority among the law enforcement community, with canine (K9) units being trained to recognise the scent of peroxide explosives. Herein, the metabolism, blood distribution, and toxicity of peroxide explosives are investigated.HMTD metabolism studies in liver microsomes identified two potential metabolites, tetramethylene diperoxide diamine alcohol aldehyde (TMDDAA) and tetramethylene peroxide diamine dialcohol dialdehyde (TMPDDD).Blood stability studies in dogs and humans showed that HMTD was rapidly degraded, whereas TATP remained for at least one week.Toxicity studies in dog and human hepatocytes indicated minimum cell death for both TATP and HMTD.
三丙酮三过氧化合物（TATP）和六亚甲基三过氧化二胺（HMTD）是显著的爆炸威胁。减轻过氧化物炸药的危害是执法部门的首要任务，警犬（K9）部队正在接受训练以识别过氧化物炸药的气味。在此，对过氧化物炸药的代谢、血液分布和毒性进行了研究。在肝微粒体中进行的HMTD代谢研究确定了两种潜在代谢物，四亚甲基二过氧化二胺醇醛（TMDDAA）和四亚甲基过氧化二胺二醇二醛（TMPDDD）。在狗和人类身上进行的血液稳定性研究表明，HMTD迅速降解，而TATP至少留存一周。在狗和人类肝细胞中进行的毒性研究表明，TATP和HMTD导致的细胞死亡最少。
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