Jiang Dandan, Peng Liying, Wen Meng, Zhou Qinghua, Chen Chuang, Wang Xin, Chen Wendong, Li Haiyang
Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian, Liaoning 116023, People's Republic of China.
Graduate University of Chinese Academy of Sciences , Beijing, 100049, People's Republic of China.
Anal Chem. 2016 Apr 19;88(8):4391-9. doi: 10.1021/acs.analchem.5b04830. Epub 2016 Apr 8.
Peroxide explosives, such as triacetone triperoxide (TATP) and hexamethylene trioxide diamine (HMTD), were often used in the terrorist attacks due to their easy synthesis from readily starting materials. Therefore, an on-site detection method for TATP and HMTD is urgently needed. Herein, we developed a stand-alone dopant-assisted positive photoionization ion mobility spectrometry (DAPP-IMS) coupled with time-resolved thermal desorption introduction for rapid and sensitive detection of TATP and HMTD in complex matrices, such as white solids, soft drinks, and cosmetics. Acetone was chosen as the optimal dopant for better separation between reactant ion peaks and product ion peaks as well as higher sensitivity, and the limits of detection (LODs) of TATP and HMTD standard samples were 23.3 and 0.2 ng, respectively. Explosives on the sampling swab were thermally desorbed and carried into the ionization region dynamically within 10 s, and the maximum released concentration of TATP or HMTD could be time-resolved from the matrix interference owing to the different volatility. Furthermore, with the combination of the fast response thermal desorber (within 0.8 s) and the quick data acquisition software to DAPP-IMS, two-dimensional data related to drift time (TATP: 6.98 ms, K0 = 2.05 cm(2) V(-1) s(-1); HMTD: 9.36 ms, K0 = 1.53 cm(2) V(-1) s(-1)) and desorption time was obtained for TATP and HMTD, which is beneficial for their identification in complex matrices.
过氧化物炸药，如三丙酮三过氧化物（TATP）和六亚甲基三过氧化二胺（HMTD），由于其易于由易得的起始原料合成，常被用于恐怖袭击。因此，迫切需要一种现场检测TATP和HMTD的方法。在此，我们开发了一种独立的掺杂剂辅助正光电离离子迁移谱（DAPP-IMS），结合时间分辨热解吸进样，用于快速灵敏地检测复杂基质（如白色固体、软饮料和化妆品）中的TATP和HMTD。选择丙酮作为最佳掺杂剂，以实现反应物离子峰和产物离子峰之间的更好分离以及更高的灵敏度，TATP和HMTD标准样品的检测限分别为23.3 ng和0.2 ng。采样拭子上的炸药在10 s内被热解吸并动态带入电离区域，由于挥发性不同，TATP或HMTD的最大释放浓度可从基质干扰中实现时间分辨。此外，结合快速响应热解吸器（0.8 s内）和DAPP-IMS的快速数据采集软件，获得了TATP和HMTD的与漂移时间（TATP：6.98 ms，K0 = 2.05 cm² V⁻¹ s⁻¹；HMTD：9.36 ms，K0 = 1.53 cm² V⁻¹ s⁻¹）和解吸时间相关的二维数据，这有利于它们在复杂基质中的鉴定。
