Universidade Federal do Paraná, Complexo Hospital de Clínicas, Curitiba, PR, Brazil.
Universidade Federal do Paraná, Curitiba, PR, Brazil.
Rev Lat Am Enfermagem. 2021 Jan 8;29:e3385. doi: 10.1590/1518-8345.3310.3385. eCollection 2021.
to evaluate the effectiveness of the 50 IU/mL heparin solution compared to the 0.9% isotonic saline solution in preventing occlusion of the double lumen Hickman® catheter, 7 and 9 French, in patients undergoing hematopoietic stem cell transplantation.
a triple-blind randomized clinical trial. 17 double-lumen catheters (heparin group: n=7 and 0.9% isotonic saline group: n=10) were analyzed in which the two catheter routes were evaluated separately, totaling 34 lumens. The outcome variables were occlusion without reflux and complete occlusion. Descriptive analyses were performed using the Chi-square test and, of survival, according to the Kaplan-Meier test.
the mean number of days until the occlusion outcome was 52 in the heparin group and 13.46 in the 0.9% isotonic saline group in the white catheter route (p<0.001). In the red route, the mean follow-up days in the heparin group were 35.29, with no occlusion and 22.30 in the 0.9% isotonic saline group until the first occlusion (p=0.030).
blocking with 50 IU/mL heparin solution is more effective than 0.9% isotonic saline in preventing occlusion of the Hickman® catheter. Brazilian Registry of Clinical Trials: RBR-3ht499.
评估 50IU/mL 肝素溶液与 0.9%生理盐水在预防造血干细胞移植患者使用 7 法国和 9 法国双腔 Hickman®导管堵塞方面的有效性。
一项三盲随机临床试验。分析了 17 个双腔导管（肝素组：n=7 和 0.9%生理盐水组：n=10），分别评估了两条导管通路，共计 34 个腔道。结局变量为无反流和完全闭塞的导管堵塞。采用卡方检验进行描述性分析，采用 Kaplan-Meier 检验进行生存分析。
肝素组白色导管通路的导管堵塞结局的平均天数为 52 天，0.9%生理盐水组为 13.46 天（p<0.001）。在红色导管通路中，肝素组的平均随访天数为 35.29 天，无堵塞，而 0.9%生理盐水组在第一次堵塞前为 22.30 天（p=0.030）。
与 0.9%生理盐水相比，50IU/mL 肝素溶液在预防 Hickman®导管堵塞方面更有效。巴西临床试验注册处：RBR-3ht499。
