成纤维细胞及其在肺纤维化慢性损伤中的反应。

Fibroblasts and their responses to chronic injury in pulmonary fibrosis.

机构信息

Schroeder Arthritis Institute, University Health Network, Toronto, Ontario, Canada; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada; Departments of Surgery and of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

出版信息

Semin Arthritis Rheum. 2021 Feb;51(1):310-317. doi: 10.1016/j.semarthrit.2020.12.003. Epub 2020 Dec 10.

DOI:10.1016/j.semarthrit.2020.12.003

PMID:33440304

Abstract

The field of pulmonary fibrosis is rapidly expanding as new insights highlight novel mechanisms that influence fibroblast biology and likely promote aberrant and chronic activation of the tissue repair response. Current paradigms suggest repeated epithelial microinjury as a driver for pathology; however, the rapid expansion of pulmonary fibrosis research calls for an overview on how fibroblasts respond to both neighbouring cells and the injury microenvironment. This review seeks to highlight recent discoveries and identify areas that require further research regarding fibroblasts, and their role in pulmonary fibrosis.

摘要

肺纤维化领域正在迅速发展，新的研究进展揭示了影响成纤维细胞生物学的新机制，并可能促进组织修复反应的异常和慢性激活。目前的范式表明，上皮细胞的反复微小损伤是导致病变的原因；然而，肺纤维化研究的迅速发展需要对成纤维细胞以及它们对邻近细胞和损伤微环境的反应有一个概述。本文旨在强调成纤维细胞的最新发现，并确定需要进一步研究的领域及其在肺纤维化中的作用。