Department of Pharmacy, Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200240, People's Republic of China.
Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Drug Des Devel Ther. 2024 May 17;18:1627-1650. doi: 10.2147/DDDT.S388920. eCollection 2024.
With ever-increasing intensive studies of idiopathic pulmonary fibrosis (IPF), significant progresses have been made. Endoplasmic reticulum stress (ERS)/unfolded protein reaction (UPR) is associated with the development and progression of IPF, and targeting ERS/UPR may be beneficial in the treatment of IPF. Natural product is a tremendous source of new drug discovery, and accumulating studies have reported that many natural products show potential therapeutic effects for IPF via modulating one or more branches of the ERS signaling pathway. Therefore, this review focuses on critical roles of ERS in IPF development, and summarizes herbal preparations and bioactive compounds which protect against IPF through regulating ERS.
随着对特发性肺纤维化 (IPF) 的深入研究，已经取得了重大进展。内质网应激 (ERS)/未折叠蛋白反应 (UPR) 与 IPF 的发生和发展有关，靶向 ERS/UPR 可能对 IPF 的治疗有益。天然产物是新药发现的巨大来源，越来越多的研究报道，许多天然产物通过调节 ERS 信号通路的一个或多个分支显示出对 IPF 的潜在治疗作用。因此，本综述重点关注 ERS 在 IPF 发展中的关键作用，并总结了通过调节 ERS 来防治 IPF 的草药制剂和生物活性化合物。
