Department of Internal Medicine (Psychologic Clinic), Cancer Hospital of China Medical University, Shenyang, 110042, China.
Department of Psychology Clinic, Shengjing Hospital of China Medical University, Shenyang, 110022, China.
Syst Rev. 2021 Jan 13;10(1):26. doi: 10.1186/s13643-020-01571-8.
Phantom limb pain (PLP) is a prevalent problem for children after amputation because of the chemotherapy treatment. Gabapentin is a potential option to manage PLP after amputation in pediatric oncology. However, no systematic review specifically investigated this topic. Thus, this study aims to appraise the efficacy and safety of gabapentin for post-amputation PLP in pediatric oncology.
Electronic databases (Cochrane Library, MEDLINE, EMBASE, Web of Science, CINAHL, PsychINFO, Scopus, WANGFANG, and Chinese Biomedical Literature Database) will be systematically searched from the beginning to the present without limitations to publication status and language. Primary outcome is pain intensity. Secondary outcomes are analgesic drug consumption, sleep quality, depression, anxiety, health-related quality of life, and adverse events. The treatment effect of all dichotomous outcome data will be estimated as risk ratio and 95% confidence intervals (CIs) and that of continuous outcome data will be calculated as mean difference or standardized mean difference and 95% CIs. Methodological quality of randomized controlled trials (RCTs) will be assessed using Cochrane risk of bias tool and that of case-controlled studies (CCSs) will be appraised using Newcastle-Ottawa Tool. Statistical analysis will be conducted using RevMan 5.3 software.
This study will summarize up-to-date high-quality RCTs and CCSs to assess the efficacy and safety of gabapentin for PLP after amputation in pediatric oncology. The findings of this study will help to determine whether or not gabapentin is effective and safe for children with PLP after amputation.
INPLASY202060090.
由于化疗治疗，儿童截肢后常出现幻肢痛（PLP）。加巴喷丁是小儿肿瘤截肢后管理 PLP 的潜在选择。然而，尚无专门针对该主题的系统评价。因此，本研究旨在评估加巴喷丁治疗小儿肿瘤截肢后 PLP 的疗效和安全性。
将系统地从开始到现在在电子数据库（Cochrane 图书馆、MEDLINE、EMBASE、Web of Science、CINAHL、PsychINFO、Scopus、WANGFANG 和中国生物医学文献数据库）中搜索，不受出版物状态和语言的限制。主要结局是疼痛强度。次要结局是镇痛药消耗、睡眠质量、抑郁、焦虑、健康相关生活质量和不良事件。所有二分类结局数据的治疗效果将估计为风险比和 95%置信区间（CI），连续结局数据的治疗效果将计算为均数差或标准化均数差和 95%CI。将使用 Cochrane 偏倚风险工具评估随机对照试验（RCTs）的方法学质量，使用纽卡斯尔-渥太华工具评估病例对照研究（CCS）的方法学质量。统计分析将使用 RevMan 5.3 软件进行。
本研究将总结最新的高质量 RCT 和 CCS，以评估加巴喷丁治疗小儿肿瘤截肢后 PLP 的疗效和安全性。本研究的结果将有助于确定加巴喷丁是否对截肢后 PLP 儿童有效且安全。
INPLASY202060090。
