Istanbul Research and Education Hospital, Endocrinology and Metabolism Department, Kasap İlyas Mah, Org. Abdurrahman Nafiz Gürman Cd., 34098 Fatih, Istanbul, Turkey.
Afyon Kocatepe University Endocrinology and Metabolism Department, Erenler, Gazlıgöl Yolu Rektörlük E Blok, 03200 Afyon,Turkey.
Prim Care Diabetes. 2021 Jun;15(3):424-427. doi: 10.1016/j.pcd.2021.01.003. Epub 2021 Jan 9.
The impact of prolonged COVID-19 lockdown on metabolic control in type 2 diabetes patients and healthy individuals has not exactly been known. We aimed to evaluate the change in body weight and metabolic control in type 2 diabetic and non-diabetic healthy subjects during the prolonged lockdown period.
Diabetic (n = 85), and age-and sex-matched non-diabetic subjects (n = 55) were included in this prospective study. Body mass index and metabolic parameters were compared between before and 6th months of lockdown. Changes in values were evaluated using the difference before and after lockdown.
Age (54.81 ± 10.53 vs. 52.61 ± 4.88 years), gender (female, 68.2% vs. 56.4%) and, BMI (33.44 ± 6.48 vs. 31.63 ± 3.57 kg/m) were similar between groups (p > 0.05). Before and after lockdown, BMI increased both in non-diabetic (0.54 ± 0.95 kg) and diabetic groups (1.91 ± 5.48 kg) (p > 0.05). Increase in HbA1c was more in diabetic than in non-diabetic groups (0.71 ± 1.35 vs. 0.02 ± 0.19%, p = 0.002). Glucose, LDL-C, and TG increased in diabetic (39.69 ± 74.69, 7.60 ± 34.33, and 58.21 ± 133.54 mg/dl, p < 0.05) whereas non significantly decreased in non-diabetic group (-0.51 ± 4.40, -3.52 ± 14.53, and -6.47 ± 41.77 mg/dl, respectively. After adjusting BMI, increase in blood glucose (p = 0.021), HbA1c (p = 0.018), and TG (p = 0.041) levels were more in diabetic than non-diabetic group. Duration of diabetes was an independent predictor of the change in HbA1c (OR: 1.2, 95% CI = 1.1-1.8, p = 0.032).
Body weight gain was observed in type 2 diabetic patients and healthy subjects. This is the first study to show that prolonged lockdown COVID-19 pandemic worsened glucose regulation and increased TG level in diabetes mellitus independent of weight gain.
目前尚不清楚 COVID-19 长期封锁对 2 型糖尿病患者和健康个体代谢控制的影响。我们旨在评估 2 型糖尿病和非糖尿病健康受试者在长期封锁期间体重和代谢控制的变化。
这项前瞻性研究纳入了 85 例糖尿病患者和 55 例年龄和性别匹配的非糖尿病患者。比较了封锁前和封锁后 6 个月的体重指数和代谢参数。使用封锁前后的差值评估值的变化。
两组的年龄（54.81 ± 10.53 岁比 52.61 ± 4.88 岁）、性别（女性，68.2%比 56.4%）和 BMI（33.44 ± 6.48 千克/平方米比 31.63 ± 3.57 千克/平方米）相似（p>0.05）。在非糖尿病患者（0.54 ± 0.95 千克）和糖尿病患者（1.91 ± 5.48 千克）中，BMI 在封锁前后均增加（p>0.05）。与非糖尿病组相比，糖尿病组的 HbA1c 升高更明显（0.71 ± 1.35 比 0.02 ± 0.19%，p=0.002）。在糖尿病患者中，血糖（39.69 ± 74.69 毫克/分升）、LDL-C（7.60 ± 34.33 毫克/分升）和 TG（58.21 ± 133.54 毫克/分升）升高，而非糖尿病患者中这些指标均未显著降低（分别为-0.51 ± 4.40、-3.52 ± 14.53 和-6.47 ± 41.77 毫克/分升）。在调整 BMI 后，与非糖尿病组相比，糖尿病组的血糖（p=0.021）、HbA1c（p=0.018）和 TG（p=0.041）水平升高更为明显。糖尿病病程是 HbA1c 变化的独立预测因素（OR：1.2，95%CI=1.1-1.8，p=0.032）。
2 型糖尿病患者和健康受试者的体重均增加。这是第一项表明 COVID-19 大流行长期封锁会加重糖尿病患者的血糖调节并增加 TG 水平，而与体重增加无关的研究。
