Experimental Medicine Department, Sapienza University of Rome, Latina, Italy.
Endocrinology and Diabetes Unit, Campus Bio-Medico University of Rome, Rome, Italy.
Diabetes Obes Metab. 2021 Jul;23(7):1624-1630. doi: 10.1111/dom.14380. Epub 2021 Apr 6.
To assess the effect of the coronavirus disease 2019 (COVID-19) lockdown on glycaemic control in subjects with type 2 diabetes (T2D).
In this observational, multicentre, retrospective study conducted in the Lazio region, Italy, we compared the differences in the HbA1c levels of 141 subjects with T2D exposed to lockdown with 123 matched controls with T2D who attended the study centres 1 year before. Basal data were collected from 9 December to 9 March and follow-up data from 3 June to 10 July in 2020 for the lockdown group, and during the same timeframes in 2019 for the control groups. Changes in HbA1c (ΔHbA1c) and body mass index (ΔBMI) during lockdown were compared among patients with different psychological well-being, as evaluated by tertiles of the Psychological General Well-Being Index (PGWBS).
No difference in ΔHbA1c was found between the lockdown and control groups (lockdown group -0.1% [-0.5%-0.3%] vs. control group -0.1% [-0.4%-0.2%]; p = .482). Also, no difference was found in ΔBMI (p = .316) or ΔGlucose (p = .538). In the lockdown group, subjects with worse PGWBS showed a worsening of HbA1c (p = .041 for the trend among PGWBS tertiles) and BMI (p = .022).
The COVID-19 lockdown did not significantly impact glycaemic control in people with T2D. People with poor psychological well-being may experience a worsening a glycaemic control because of restrictions resulting from lockdown. These findings may aid healthcare providers in diabetes management once the second wave of COVID-19 has ended.
评估 2019 年冠状病毒病（COVID-19）封锁对 2 型糖尿病（T2D）患者血糖控制的影响。
在意大利拉齐奥地区进行的这项观察性、多中心、回顾性研究中，我们比较了暴露于封锁下的 141 名 T2D 患者和 123 名匹配的 T2D 对照组在 HbA1c 水平上的差异。基础数据于 2020 年 12 月 9 日至 3 月 9 日收集，随访数据于 6 月 3 日至 7 月 10 日收集，封锁组和对照组分别在 2019 年同期进行。通过心理总体幸福感指数（PGWBS）的三分位数评估不同心理幸福感的患者在封锁期间的 HbA1c（ΔHbA1c）和体重指数（ΔBMI）的变化。
封锁组和对照组之间的 ΔHbA1c 无差异（封锁组-0.1%[-0.5%-0.3%]vs.对照组-0.1%[-0.4%-0.2%]；p=0.482）。ΔBMI（p=0.316）或ΔGlucose（p=0.538）也无差异。在封锁组中，PGWBS 较差的患者 HbA1c 恶化（PGWBS 三分位的趋势 p=0.041）和 BMI 恶化（p=0.022）。
COVID-19 封锁并未显著影响 T2D 患者的血糖控制。心理幸福感较差的人可能会因封锁造成的限制而出现血糖控制恶化。这些发现可能有助于医疗保健提供者在 COVID-19 第二波疫情结束后进行糖尿病管理。
