Pathology, Kuwait Cancer Control Center, Shuwaikh, Al Asimah, Kuwait.
Department of Histopathology, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK
J Clin Pathol. 2021 Mar;74(3):137-140. doi: 10.1136/jclinpath-2020-207174. Epub 2021 Jan 13.
is the human homologue belonging to a family of four genes and is located on chromosome 9q21. It consists of 19 exons. Although it does not bind directly to DNA, it acts as a repressor of several signalling pathways via transcription factors. TLE1 protein has several physiological roles in embryogenesis, haematopoiesis, general differentiation, and both neuronal and eye development. Much attention was focused on its expression in the tumour cell nuclei of synovial sarcoma (SS). However, several other soft tissue tumours that do and do not share morphological similarity with SS also display nuclear immunoreactivity for TLE1; hence, caution in interpretation is advocated.
是一种人类同源物，属于四个基因家族之一，位于染色体 9q21 上。它由 19 个外显子组成。尽管它不能直接与 DNA 结合，但它通过转录因子作为几种信号通路的抑制剂发挥作用。TLE1 蛋白在胚胎发生、造血、一般分化以及神经元和眼睛发育中具有多种生理作用。人们非常关注它在滑膜肉瘤 (SS) 肿瘤细胞核中的表达。然而，其他几种与 SS 形态上不相似的软组织肿瘤也显示出 TLE1 的核免疫反应性；因此，建议在解释时要谨慎。
