Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki-shi, Sakamoto 1-12-4, Nagasaki, 852-8523, Japan.
Department of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka, Japan.
Sci Rep. 2021 Jan 13;11(1):1088. doi: 10.1038/s41598-020-80163-x.
Serum sodium concentration within the normal range could act as an indicator of age-related changes such as decrease in muscle strength and impairment of capillary function. Since endothelial injury stimulates endothelial repair by enhancing CD34-positive cell production, the level of serum sodium may be inversely associated with that of circulating CD34-positive cells, thus indicating the degree of age-related endothelial injury. We conducted a cross-sectional study of 246 elderly Japanese men aged 60-69 years. Subjects were stratified by hypertension status because hypertension should act as a strong confounding factor for the analyses performed in this study. Serum sodium concentration was positively associated with handgrip strength in non-hypertensive subjects [standardized parameter estimate (β) = 0.29; p = 0.003], but not for hypertensive subjects (β = 0.01; p = 0.878), while it was inversely associated with circulating CD34-positive cell levels in non-hypertensive subjects [simple correlation coefficient (r) = - 0.28; p = 0.002] but not for hypertensive subjects (r = - 0.07; p = 0.454). For non-hypertensive elderly subjects, serum sodium concentration within the normal range is positively associated with handgrip strength and inversely associated with CD34-positive cells, thus partly indicating the degree of age-related endothelium injury. These associations could prove to be an efficient tool for clarifying the background mechanism governing the decrease in age-related muscle strength.
血清钠浓度在正常范围内可能是与年龄相关的变化的一个指标，如肌肉力量下降和毛细血管功能受损。由于内皮损伤通过增强 CD34 阳性细胞的产生来刺激内皮修复，血清钠水平可能与循环 CD34 阳性细胞的水平呈负相关，从而表明与年龄相关的内皮损伤程度。我们对 246 名年龄在 60-69 岁的日本老年男性进行了一项横断面研究。由于高血压应该是本研究分析中的一个强有力的混杂因素，因此根据高血压状况对受试者进行分层。在非高血压受试者中，血清钠浓度与握力呈正相关[标准化参数估计值（β）= 0.29；p = 0.003]，但在高血压受试者中则无相关性（β= 0.01；p = 0.878），而在非高血压受试者中，血清钠浓度与循环 CD34 阳性细胞水平呈负相关[简单相关系数（r）= - 0.28；p = 0.002]，但在高血压受试者中则无相关性（r = - 0.07；p = 0.454）。对于非高血压的老年受试者，血清钠浓度在正常范围内与握力呈正相关，与 CD34 阳性细胞呈负相关，部分表明与年龄相关的内皮损伤程度。这些关联可能被证明是阐明与年龄相关的肌肉力量下降的背景机制的有效工具。
