Peterson Mark D, Duchowny Kate, Meng Qinqin, Wang Yafeng, Chen Xinxin, Zhao Yaohui
Department of Physical Medicine & Rehabilitation, University of Michigan Health System, Ann Arbor.
Global REACH, University of Michigan Medical School, Ann Arbor.
J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1525-1531. doi: 10.1093/gerona/glx031.
Evidence highlights the importance of muscular strength as a protective factor for health and function across aging populations. The purpose of this study was to examine the extent to which low normalized grip strength (NGS) serves as a biomarker for both cardiometabolic disease and physical disability in U.S. and Chinese adults.
Middle aged and older adults from the U.S. National Health and Nutrition Examination Survey 2011-2012 and 2013-2014 combined surveys (n = 4,544), and the 2011 wave of the China Health and Retirement Longitudinal Study (n = 6,030) were included. Strength was assessed using a handgrip dynamometer, and was normalized to body mass. Weighted logistic regression models were used to assess the association between NGS and diabetes, hyperglycemia, hypertriglyceridemia, low HDL-cholesterol, hypertension, and physical disability status, while controlling for age, sex, and sociodemographic characteristics.
Every 0.05 lower NGS was independently associated with a 1.49 (95% confidence interval [CI]: 1.42-1.56) and 1.17 (95% CI: 1.11-1.23) odds for diabetes; a 1.46 (95% CI: 1.39-1.53) and 1.11 (95% CI: 1.07-1.15) odds of hyperglycemia; a 1.15 (95% CI: 1.07-1.25) and 1.11 (95% CI: 1.08-1.14) odds of hypertriglyceridemia; a 1.22 (95% CI: 1.17-1.27) and 1.15 (95% CI: 1.12-1.18) odds of low HDL-cholesterol; a 1.19 (95% CI: 1.14-1.24) and 1.10 (95% CI: 1.07-1.14) odds of hypertension; and a 1.36 (95% CI: 1.29-1.42) and 1.10 (95% CI: 1.05-1.15) odds for physical disability status in U.S. and Chinese adults, respectively.
NGS was robustly associated with both cardiometabolic disease risk and physical disabilities in U.S. and Chinese aging adults.
有证据表明，肌肉力量作为各年龄段人群健康和功能的保护因素具有重要意义。本研究旨在探讨低标准化握力（NGS）在美国和中国成年人中作为心血管代谢疾病和身体残疾生物标志物的程度。
纳入了来自美国2011 - 2012年和2013 - 2014年综合调查的国家健康与营养检查调查（n = 4544）的中年及老年人，以及中国健康与养老追踪调查2011年的数据（n = 6030）。使用握力计评估力量，并根据体重进行标准化。采用加权逻辑回归模型评估NGS与糖尿病、高血糖、高甘油三酯血症、低高密度脂蛋白胆固醇、高血压和身体残疾状况之间的关联，同时控制年龄、性别和社会人口学特征。
在美国和中国成年人中，NGS每降低0.05分别独立地与糖尿病的比值比为1.49（95%置信区间[CI]：1.42 - 1.56）和1.17（95%CI：1.11 - 1.23）；高血糖的比值比为1.46（95%CI：1.39 - 1.53）和1.11（95%CI：1.07 - 1.15）；高甘油三酯血症的比值比为1.15（95%CI：1.07 - 1.25）和1.11（95%CI：1.08 - 1.14）；低高密度脂蛋白胆固醇的比值比为1.22（95%CI：1.17 - 1.27）和1.15（95%CI：1.12 - 1.18）；高血压的比值比为1.19（95%CI：1.14 - 1.24）和1.10（95%CI：1.07 - 1.14）；身体残疾状况的比值比为1.36（95%CI：1.29 - 1.42）和1.10（95%CI：1.05 - 1.15）相关。
在美国和中国的老年成年人中，NGS与心血管代谢疾病风险和身体残疾均密切相关。
