Yamanashi H, Shimizu Y, Koyamatsu J, Nagayoshi M, Kadota K, Tamai M, Maeda T
Hirotomo Yamanashi, MD, Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Goto, Nagasaki 853-8691, Japan, E-mail:
J Frailty Aging. 2017;6(1):6-11. doi: 10.14283/jfa.2016.107.
Handgrip strength is a simple measurement of overall muscular strength and is used to detect sarcopenia. It also predicts adverse events in later life. Many mechanisms of sarcopenia development have been reported. A hypertensive status impairs endothelial dysfunction, which might deteriorate skeletal muscle if vascular angiogenesis is not maintained.
This study investigated muscle strength and circulating CD34-positive cells as a marker of vascular angiogenesis.
Cross-sectional study.
262 male Japanese community dwellers aged 60 to 69 years.
The participants' handgrip strength, medical history, and blood samples were taken. We stratified the participants by hypertensive status to investigate the association between handgrip strength and circulating CD34-positive cells according to hypertensive status. Pearson correlation and linear regression analyses were used.
In the Pearson correlation analysis, handgrip strength and the logarithm of circulating CD34-positive cells were significantly associated in hypertensive participants (r=0.22, p=0.021), but not in non-hypertensive participants (r=-0.01, p=0.943). This relationship was only significant in hypertensive participants (ß=1.94, p=0.021) in the simple linear regression analysis, and it remained significant after adjusting for classic cardiovascular risk factors (ß=1.92, p=0.020). The relationship was not significant in non-hypertensive participants (ß=-0.09, p=0.903).
We found a positive association between handgrip strength and circulating CD34-positive cells in hypertensive men. Vascular maintenance attributed by circulating CD34-positive cells is thought to be a background mechanism of this association after hypertension-induced vascular injury in skeletal muscle.
握力是整体肌肉力量的一种简单测量方法，用于检测肌肉减少症。它还能预测晚年的不良事件。已经报道了许多肌肉减少症发展的机制。高血压状态会损害内皮功能障碍，如果血管生成不能维持，可能会使骨骼肌恶化。
本研究调查了肌肉力量和循环CD34阳性细胞作为血管生成标志物的情况。
横断面研究。
262名年龄在60至69岁之间的日本男性社区居民。
采集参与者的握力、病史和血液样本。我们根据高血压状态对参与者进行分层，以研究握力与循环CD34阳性细胞之间的关联。采用Pearson相关性分析和线性回归分析。
在Pearson相关性分析中，高血压参与者的握力与循环CD34阳性细胞的对数显著相关（r = 0.22，p = 0.021），而非高血压参与者则无相关性（r = -0.01，p = 0.943）。在简单线性回归分析中，这种关系仅在高血压参与者中显著（β = 1.94，p = 0.021），在调整经典心血管危险因素后仍显著（β = 1.92，p = 0.020）。在非高血压参与者中，这种关系不显著（β = -0.09，p = 0.903）。
我们发现高血压男性的握力与循环CD34阳性细胞之间存在正相关。循环CD34阳性细胞所赋予的血管维持作用被认为是骨骼肌高血压诱导的血管损伤后这种关联的一个背景机制。
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