Department of Mechanical Engineering, Hanyang University College of Engineering, Seoul, Korea.
Department of Ophthalmology, Hanyang University College of Medicine, Wangsimni-ro 222, Seongdong-gu, Seoul, 04763, Korea.
Sci Rep. 2021 Jan 13;11(1):1264. doi: 10.1038/s41598-020-80321-1.
The present study aimed to identify vibroacoustic properties associated with intraocular pressure (IOP) changes and to suggest a new way to measure the IOP based on these properties. Ten ex vivo porcine eyeballs were used in this study. Each eyeball was fixated in a central hole of a Styrofoam block, and vibration applied to the Styrofoam block was transmitted to the eyeball. An accelerometer directly attached to the eyeball measured the vibration response. Excitations and measurements were performed for 1 s, and the excitation magnitude was varied for the same signal in repeat measurements. A 30-gauge needle was inserted into the anterior chamber of the eyeball to inject a balanced salt solution, and the height of the bottle was adjusted to adjust the IOP. A tonometer was used under identical conditions to measure the IOP five times, and the mean value was determined for further analyses. The measurements showed that the parameters resonance frequency and change in the magnitude of the vibration response (CMVR) increased with rising IOP values. The CMVR was highly correlated with the IOP (p-value < 0.0001). A linear mixed effects model (LMM) was used as a statistical analysis method. We confirmed that vibroacoustic properties of the eyeball are correlated with IOP changes. It is expected that the CMVR will serve as a new parameter for IOP measurements. Thus, in the future, continuous IOP measurements would be easily performed using the CMVR.
本研究旨在确定与眼内压 (IOP) 变化相关的振动声学特性，并基于这些特性提出一种新的 IOP 测量方法。本研究使用了 10 个离体猪眼球。每个眼球都固定在泡沫聚苯乙烯块的中心孔中，施加到泡沫聚苯乙烯块的振动会传递到眼球。一个直接附着在眼球上的加速度计测量振动响应。激励和测量持续 1 秒，在重复测量中对相同信号改变激励幅度。将 30 号针头插入眼球前房以注入平衡盐溶液，并调整瓶的高度以调整 IOP。在相同条件下使用眼压计五次测量 IOP，并确定平均值进行进一步分析。测量结果表明，共振频率和振动响应幅度变化（CMVR）等参数随 IOP 值的升高而增加。CMVR 与 IOP 高度相关（p 值<0.0001）。线性混合效应模型 (LMM) 被用作统计分析方法。我们证实眼球的振动声学特性与 IOP 变化相关。预计 CMVR 将成为测量 IOP 的新参数。因此，未来将能够使用 CMVR 轻松进行连续的 IOP 测量。
