Hussain Suhaimi, Men Khoo Kay, Majid Noorizan Abd
Department of Paediatrics, School of Medical Sciences, Universiti Sains Malaysia.
J ASEAN Fed Endocr Soc. 2017;32(2):132-138. doi: 10.15605/jafes.032.02.06. Epub 2017 Oct 14.
We aim to compare the clinical and biochemical profile of metabolic syndrome between obese children below and above 10 years attending Paediatric clinic Hospital Universiti Sains Malaysia (HUSM) from 2006 to 2015. This is to determine if age, particularly the transition to puberty, modifies the prevalence of components of metabolic syndrome in obese children.
The medical records of 84 obese children under 18 years of age seen at Paediatric clinic HUSM from 2006 to 2015 were reviewed. Demographic (age, gender, ethnicity), anthropometric (weight and height), clinical [body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP)] and biochemical [serum total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), fasting plasma glucose (FPG)] parameters were recorded, analyzed and compared.
Majority of subjects in both age groups were boys, with 68.2% <10 years old. Mean age was 9.69 years (±3.36). The clinical and biochemical parameters of metabolic syndrome were similar between those <10 years old and >10 years, with the exception of BMI, waist circumference, SBP and TG level. Multivariate regression analysis showed that the parameters of metabolic syndrome significantly associated with age ≥10 years were systolic hypertension (adjusted OR 7.17, 95% CI, 1.48 to 34.8) and BMI >30 kg/m (adjusted OR 3.02, 95% CI, 1.16 to 7.86).
There were similar clinical and biochemical parameters of metabolic syndrome in both age groups. The proportions of children with metabolic syndrome were similar regardless of age group. The overall prevalence rate of metabolic syndrome was 27.3%. In view of the alarming presence of components of metabolic syndrome even in children less than 10 years of age, efforts aimed at the prevention of childhood obesity in the community should be intensified.
我们旨在比较2006年至2015年期间在马来西亚理科大学医院（HUSM）儿科门诊就诊的10岁以下和10岁以上肥胖儿童代谢综合征的临床和生化特征。这是为了确定年龄，特别是青春期过渡，是否会改变肥胖儿童代谢综合征各组成部分的患病率。
回顾了2006年至2015年期间在HUSM儿科门诊就诊的84名18岁以下肥胖儿童的病历。记录、分析并比较了人口统计学（年龄、性别、种族）、人体测量学（体重和身高）、临床[体重指数（BMI）、收缩压（SBP）和舒张压（DBP）]以及生化[血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖（FPG）]参数。
两个年龄组的大多数受试者为男孩，10岁以下的占68.2%。平均年龄为9.69岁（±3.36）。除BMI、腰围、SBP和TG水平外，10岁以下和10岁以上儿童代谢综合征的临床和生化参数相似。多变量回归分析显示，与10岁及以上年龄显著相关的代谢综合征参数为收缩期高血压（校正比值比7.17，95%可信区间，1.48至34.8）和BMI>30 kg/m（校正比值比3.02，95%可信区间，1.16至7.86）。
两个年龄组代谢综合征的临床和生化参数相似。无论年龄组如何，代谢综合征儿童的比例相似。代谢综合征的总体患病率为27.3%。鉴于即使在10岁以下儿童中也存在令人担忧的代谢综合征组成部分，应加强社区预防儿童肥胖的努力。
