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Hypoglycaemia during pregnancy in women with Type 1 diabetes.孕妇 1 型糖尿病患者的低血糖症。
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血糖得到严格控制的接受胰岛素治疗的糖尿病孕妇中低血糖的患病率。

Prevalence of Hypoglycaemia among Insulin-Treated Pregnant Women with Diabetes Who Achieved Tight Glycaemic Control.

作者信息

Ng Danish, Noor Nurain Mohd, Yong Sy Liang

机构信息

Department of Medicine, Tengku Ampuan, Rahimah Hospital, Klang, Ministry of Health, Malaysia.

Department of Medicine, Putrajaya Hospital, Ministry of Health, Malaysia.

出版信息

J ASEAN Fed Endocr Soc. 2019;34(1):29-35. doi: 10.15605/jafes.034.01.06. Epub 2019 Apr 15.

DOI:10.15605/jafes.034.01.06
PMID:33442134
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7784197/
Abstract

OBJECTIVES

To determine the prevalence of hypoglycaemia using continuous glucose monitoring system (CGMS) among insulin-treated pregnant women with diabetes whose glycosylated haemoglobin (HbA1c) were <6.0% and identify the risk factors associated with hypoglycaemia occurrence.

METHODOLOGY

We conducted a cross-sectional study using 6-days CGMS to detect the prevalence of hypoglycaemia in 31 insulin-treated pregnant women with diabetes who achieved HbA1c <6.0%. Patients were required to log-keep their self-monitoring blood glucose (SMBG) readings and hypoglycaemia events.

RESULTS

Eight women experienced confirmed hypoglycaemia with additional seven experienced relative hypoglycaemia, giving rise to prevalence rate of 45.2% (one had both confirmed and relative hypoglycaemia). Nine relative hypoglycaemia and 17 confirmed hypoglycaemic events were recorded. Sixteen (94%) out of 17 confirmed hypoglycaemia events recorded by CGMS were asymptomatic and were missed despite performing regular SMBG. Nocturnal hypoglycaemia events were recorded in seven women. Univariable analysis did not identify any association between conventional risk factors and hypoglycaemia events in our cohort.

CONCLUSION

Insulin-treated pregnant women with diabetes who achieved HbA1c <6.0% were associated with high prevalence of hypoglycaemia. Asymptomatic hypoglycaemia is common in our cohort and frequently missed despite regular SMBG. Present study did not identify any association between conventional risk factors and hypoglycaemia events in our cohort.

摘要

目的

使用连续血糖监测系统（CGMS）确定糖化血红蛋白（HbA1c）<6.0%的胰岛素治疗糖尿病孕妇中低血糖的患病率，并确定与低血糖发生相关的危险因素。

方法

我们进行了一项横断面研究，使用6天的CGMS检测31例HbA1c<6.0%的胰岛素治疗糖尿病孕妇中低血糖的患病率。患者需要记录自我监测血糖（SMBG）读数和低血糖事件。

结果

8名女性经历了确诊低血糖，另有7名经历了相对低血糖，患病率为45.2%（1名同时有确诊和相对低血糖）。记录了9次相对低血糖和17次确诊低血糖事件。CGMS记录的17次确诊低血糖事件中有16次（94%）无症状，尽管进行了常规SMBG仍未被发现。7名女性记录到夜间低血糖事件。单因素分析未发现我们队列中传统危险因素与低血糖事件之间存在任何关联。

结论

HbA1c<6.0%的胰岛素治疗糖尿病孕妇低血糖患病率较高。无症状低血糖在我们的队列中很常见，尽管进行了常规SMBG仍经常被漏诊。本研究未发现我们队列中传统危险因素与低血糖事件之间存在任何关联。