药品生产质量管理规范级树突状细胞生成的最新进展
Recent Advances in Good Manufacturing Practice-Grade Generation of Dendritic Cells.
作者信息
Cunningham Sarah, Hackstein Holger
机构信息
Department of Transfusion Medicine and Hemostaseology, University Hospital Erlangen, Erlangen, Germany.
出版信息
Transfus Med Hemother. 2020 Dec;47(6):454-463. doi: 10.1159/000512451. Epub 2020 Oct 28.
Abstract
Dendritic cells (DCs) are pivotal regulators of immune responses, specialized in antigen presentation and bridging the gap between the innate and adaptive immune system. Due to these key features, DCs have become a pillar of the continuously growing field of cellular therapies. Here we review recent advances in good manufacturing practice strategies and their individual specificities in relation to DC production for clinical applications. These take into account both small-scale experimental approaches as well as automated systems for patient care.
摘要
树突状细胞（DCs）是免疫反应的关键调节因子，专门负责抗原呈递，并在先天免疫系统和适应性免疫系统之间架起桥梁。由于这些关键特性，DCs已成为不断发展的细胞治疗领域的支柱。在此，我们综述了与临床应用中DC生产相关的良好生产规范策略及其各自的特异性方面的最新进展。这些进展既考虑了小规模实验方法，也考虑了用于患者护理的自动化系统。
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