Macías-Rodríguez Ricardo U, Ruiz-Margáin Astrid, Román-Calleja Berenice M, Espin-Nasser May E, Flores-García Nayelli C, Torre Aldo, Galicia-Hernández Gretel, Rios-Torres Silvia L, Fernández-Del-Rivero Gabriela, Orea-Tejeda Arturo, Lozano-Cruz Oscar A
Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.
Department of Cardiology, Instituto Nacional de Enfermedades Respiratorias, Mexico City 14080, Mexico.
World J Hepatol. 2020 Dec 27;12(12):1299-1313. doi: 10.4254/wjh.v12.i12.1299.
The implementation of nutritional strategies targeting several variables at once could benefit patients with cirrhosis. Non-alcoholic beer has different compounds that exert antioxidant, anti-inflammatory and nutritional properties.
To evaluate the effect of diet + exercise and non-alcoholic beer on nutritional status, endothelial function and quality of life in patients with cirrhosis.
In this randomized open clinical trial, patients with cirrhosis were randomized into two groups: The intervention (non-alcoholic beer + diet + exercise) and control (water + diet + exercise) group. Treatment consisted of 330 mL non-alcoholic beer/day or the same amount of water, plus an individualized dietary plan and an exercise program with a pedometer-based bracelet to reach at least 5000 steps/d and > 2500 above the baseline during 8 wk. Endothelial function (flow-mediated dilation, plethysmography), biochemical and nutritional variables and quality of life (CLDQ) were evaluated.
Forty-three patients were included in the study, 21 in the control group and 22 in the intervention group. The mean age was 53.5 ± 7.8 years, 60% were women, the median MELD score was 8 (7-10) and most patients were Child-Pugh A (88%). Adherence to the interventions was > 90% in both groups, there were no adverse events and all biochemical parameters remained stable in both groups. Endothelial function improved in both groups. All measured nutritional parameters improved in the intervention group, compared to only 2 in the control group and quality of life improved in both groups; however, more domains improved in the intervention group.
The intervention consisting of non-alcoholic beer, diet and exercise seems to be safe and well tolerated in patients with cirrhosis, and shows improvement in nutritional status, endothelial function, and quality of life. These results need to be further confirmed.
同时针对多个变量实施营养策略可能使肝硬化患者受益。非酒精啤酒含有多种具有抗氧化、抗炎和营养特性的化合物。
评估饮食 + 运动以及非酒精啤酒对肝硬化患者营养状况、内皮功能和生活质量的影响。
在这项随机开放临床试验中，肝硬化患者被随机分为两组：干预组（非酒精啤酒 + 饮食 + 运动）和对照组（水 + 饮食 + 运动）。治疗方案为每天饮用330毫升非酒精啤酒或等量的水，外加个性化饮食计划和基于计步器手环的运动计划，目标是在8周内每天至少达到5000步且比基线多2500步以上。评估内皮功能（血流介导的血管舒张、体积描记法）、生化和营养变量以及生活质量（CLDQ）。
43名患者纳入研究，对照组21名，干预组22名。平均年龄为53.5 ± 7.8岁，60%为女性，中位MELD评分为8（7 - 10），大多数患者为Child - Pugh A级（88%）。两组对干预措施的依从性均> 90%，无不良事件发生，两组所有生化参数均保持稳定。两组内皮功能均有改善。干预组所有测量的营养参数均有所改善，而对照组仅2项改善，两组生活质量均有改善；然而，干预组改善的领域更多。
由非酒精啤酒、饮食和运动组成的干预措施对肝硬化患者似乎安全且耐受性良好，并显示出营养状况、内皮功能和生活质量的改善。这些结果需要进一步证实。
