Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico.
Silvio O Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Yerkes National Primate Research Center, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, United States.
Elife. 2021 Jan 14;10:e55081. doi: 10.7554/eLife.55081.
Previous studies have related pair-bonding in , the prairie vole, with plastic changes in several brain regions. However, the interactions between these socially relevant regions have yet to be described. In this study, we used resting-state magnetic resonance imaging to explore bonding behaviors and functional connectivity of brain regions previously associated with pair-bonding. Thirty-two male and female prairie voles were scanned at baseline, 24 hr, and 2 weeks after the onset of cohabitation. By using network-based statistics, we identified that the functional connectivity of a corticostriatal network predicted the onset of affiliative behavior, while another predicted the amount of social interaction during a partner preference test. Furthermore, a network with significant changes in time was revealed, also showing associations with the level of partner preference. Overall, our findings revealed the association between network-level functional connectivity changes and social bonding.
先前的研究表明，草原田鼠的配对行为与几个大脑区域的可塑性变化有关。然而，这些与社交相关的区域之间的相互作用尚未被描述。在这项研究中，我们使用静息态磁共振成像来探索与配对行为相关的大脑区域的结合行为和功能连接。在同居开始后 24 小时和 2 周，对 32 只雄性和雌性草原田鼠进行了扫描。通过使用基于网络的统计学方法，我们发现皮质纹状体网络的功能连接预测了亲附行为的开始，而另一个网络预测了在伴侣偏好测试中社交互动的数量。此外，还揭示了一个在时间上有显著变化的网络，该网络也与伴侣偏好的水平有关。总的来说，我们的研究结果揭示了网络水平的功能连接变化与社交结合之间的关联。
