Department of Biology, MassachusettsInstitute of Technology, Cambridge, United States.
Picower Institute for Learning andMemory, Massachusetts Institute of Technology, Cambridge, United States.
Elife. 2020 May 26;9:e55252. doi: 10.7554/eLife.55252.
The lateral septum (LS), which is innervated by the hippocampus, is known to represent spatial information. However, the details of place representation in the LS, and whether this place information is combined with reward signaling, remains unknown. We simultaneously recorded from rat CA1 and caudodorsal lateral septum in rat during a rewarded navigation task and compared spatial firing in the two areas. While LS place cells are less numerous than in hippocampus, they are similar to the hippocampus in field size and number of fields per cell, but with field shape and center distributions that are more skewed toward reward. Spike cross-correlations between the hippocampus and LS are greatest for cells that have reward-proximate place fields, suggesting a role for the LS in relaying task-relevant hippocampal spatial information to downstream areas, such as the VTA.
外侧隔核（LS）由海马体支配，已知其代表空间信息。然而，LS 中的位置表示的细节，以及该位置信息是否与奖励信号相结合，尚不清楚。我们在大鼠进行奖励导航任务期间同时记录大鼠 CA1 和尾侧外侧隔核的神经活动，并比较了两个区域的空间放电情况。虽然 LS 位置细胞的数量少于海马体，但它们在区域大小和每个细胞的区域数量上与海马体相似，但区域形状和中心分布更偏向于奖励。海马体和 LS 之间的尖峰交叉相关度最大的是具有接近奖励的位置场的细胞，这表明 LS 在将与任务相关的海马体空间信息中继到下游区域（例如 VTA）方面发挥作用。
