Yu Yibin, Xu Shuo, Li Sanming, Pan Hao
School of Pharmacy, Liaoning University, Shenyang 110036, China.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Biomater Sci. 2021 Mar 10;9(5):1583-1597. doi: 10.1039/d0bm01403f.
Genipin is a naturally occurring nontoxic cross-linker, which has been widely used for drug delivery due to its excellent biocompatibility, admirable biodegradability and stable cross-linked attributes. These advantages led to its extensive application in the fabrication of hydrogels for drug delivery. This review describes the physicochemical characteristics and pharmacological activities of genipin and attempts to elucidate the detailed mechanisms of the cross-linking reaction between genipin and biomaterials. The current article entails a general review of the different biomaterials cross-linked by genipin: chitosan and its derivatives, collagen, gelatin, etc. The genipin-cross-linked hydrogels for various pharmaceutical applications, including ocular drug delivery, buccal drug delivery, oral drug delivery, anti-inflammatory drug delivery, and antibiotic and antifungal drug delivery, are reported. Finally, the future research directions and challenges of genipin-cross-linked hydrogels for pharmaceutical applications are also discussed in this review.
京尼平是一种天然存在的无毒交联剂，因其优异的生物相容性、良好的生物降解性和稳定的交联特性而被广泛用于药物递送。这些优点使其在用于药物递送的水凝胶制备中得到广泛应用。本综述描述了京尼平的物理化学特性和药理活性，并试图阐明京尼平和生物材料之间交联反应的详细机制。本文对由京尼平交联的不同生物材料进行了综述：壳聚糖及其衍生物、胶原蛋白、明胶等。报道了京尼平交联水凝胶在各种药物应用中的情况，包括眼部药物递送、口腔药物递送、口服药物递送、抗炎药物递送以及抗生素和抗真菌药物递送。最后，本综述还讨论了京尼平交联水凝胶在药物应用方面未来的研究方向和挑战。
