Liu Jidan, Jiang Jinyuan, Yang Zhenke, Zeng Qiaohai, Zheng Jieying, Zhang Siying, Zheng Liyao, Zhang Shang-Shi, Liu Zhao-Qing
School of Chemistry and Chemical Engineering/Institute of Clean Energy and Materials/Guangzhou Key Laboratory for Clean Energy and Materials, Guangzhou University, Guangzhou, 510006, P. R. China.
Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China.
Org Biomol Chem. 2021 Feb 11;19(5):993-997. doi: 10.1039/d0ob02323j.
An efficient Rh(iii)-catalyzed C-H oxidative alkylation of N-aryl-7-azaindoles with cyclopropanols by merging tandem C-H and C-C cleavage was developed. This transformation features mild reaction conditions, high regioselectivity, and excellent functional group compatibility. The resulting β-aryl ketone derivatives can be readily transformed into 7-azaindole-containing π-extended polycyclic heteroarenes.
通过串联C-H和C-C裂解，开发了一种高效的铑（III）催化的N-芳基-7-氮杂吲哚与环丙醇的C-H氧化烷基化反应。该转化具有反应条件温和、区域选择性高和官能团兼容性优异的特点。所得的β-芳基酮衍生物可容易地转化为含7-氮杂吲哚的π-扩展多环杂芳烃。
