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[肠道上皮干细胞的放射生物学。单次及多次亚致死剂量预照射小鼠对小肠上皮干细胞存活剂量依赖性的影响]

[Radiobiology of stem cells in intestinal epithelium. Effect of single and multiple preliminary sublethal irradiation of mice on the dose dependence of the survival of stem cells in small intestine epithelium].

作者信息

Konopliannikova O A

出版信息

Radiobiologiia. 1988 Jan-Feb;28(1):35-8.

PMID:3344330
Abstract

After a single or three-fold whole body irradiation of mice with a dose of 4 Gy and the time interval for the proliferation to be restored (5 days or 3 weeks) the survival curve for stem cells of small intestine epithelium with regard to radiation dose was the same as that for non-preirradiated mice. This indicated that the proliferative potential of stem cells in these experimental conditions was not reduced.

摘要

用4 Gy的剂量对小鼠进行单次或三次全身照射,并设定增殖恢复的时间间隔(5天或3周)后,小肠上皮干细胞的辐射剂量存活曲线与未预先照射的小鼠相同。这表明在这些实验条件下干细胞的增殖潜力没有降低。

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