Blood Bank, Sheba Medical Center, Tel Hashomer, Israel.
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Isr Med Assoc J. 2021 Jan;23(1):7-10.
During the coronavirus disease-2019 (COVID-19) pandemic outbreak our blood bank developed protocols to guarantee accurate blood components to COVID-19 patients.
To provide convalescent whole blood donor screening strategies for patients recovering from COVID-19.
We recruited COVID-19 recovering patients who met our defined inclusion criteria for whole blood donation. All blood units were screened for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) RNA by real time reverse transcription polymerase chain reaction (RT-PCR) and SARS-COV-2 immunoglobulin G (IgG) antibodies against the S1 domain.
We screened 180 blood units from patients recovering from COVID-19. All results were negative for SARS-CoV-2 RNA and 87.2% were positive for SARS-COV-2 IgG antibodies in the plasma.
Blood component units from recovering COVID-19 patients are safe. Plasma units with positive IgG antibodies could serve as an efficient passive immunization for COVID-19 patients. Moreover, in the face of increased transfusion demand for treatment of anemia and coagulation dysfunction in critical ill COVID-19 patients, red blood cells units and random platelets units from convalescent donors can be safely transfused.
在 2019 冠状病毒病（COVID-19）大流行期间，我们的血库制定了方案，以确保向 COVID-19 患者提供准确的血液成分。
为从 COVID-19 中康复的患者提供恢复期全血供者筛选策略。
我们招募了符合我们定义的全血捐献标准的 COVID-19 康复患者。所有血液单位均通过实时逆转录聚合酶链反应（RT-PCR）和针对 S1 结构域的 SARS-COV-2 免疫球蛋白 G（IgG）抗体对严重急性呼吸综合征冠状病毒-2（SARS-CoV-2）RNA 进行筛查。
我们筛查了 180 份来自 COVID-19 康复患者的血液单位。所有结果均为 SARS-CoV-2 RNA 阴性，87.2%的血浆呈 SARS-COV-2 IgG 抗体阳性。
来自康复 COVID-19 患者的血液成分单位是安全的。具有阳性 IgG 抗体的血浆单位可作为 COVID-19 患者的有效被动免疫。此外，在面对治疗 COVID-19 危重症患者贫血和凝血功能障碍的输血需求增加的情况下，可安全输注来自恢复期供者的红细胞单位和随机血小板单位。
