Aronson Kerri I, Ali Maha, Reshetynak Evgeniya, Kaner Robert J, Martinez Fernando J, Safford Monika M, Pinheiro Laura C
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medicine New York, New York, USA.
Division of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
J Patient Rep Outcomes. 2021 Jan 14;5(1):9. doi: 10.1186/s41687-020-00282-x.
Chronic Hypersensitivity Pneumonitis (CHP) is caused by an immune mediated response in the lung tissue after exposure to an inhaled environmental antigenic stimulant. We previously documented the ways in which CHP impacts patients' lives and have now developed a disease-specific instrument, the CHP-HRQOL instrument, to measure health-related quality of life (HRQOL). The objective of this study was to assess content validity for the CHP-HRQOL.
Cognitive interviews were conducted among adults with CHP. The instrument was revised and refined between each round of interviews. Feedback was obtained on the instructions, items, response options, and recall period. Items where participants had difficulty with comprehension, wording, or misinterpretation were marked by the interviewer and participant feedback was reviewed to make revisions, add or delete items when appropriate. Readability statistics were calculated using Flesch-Kincaid grade level and reading ease scores.
Ten participants were interviewed over three rounds, with revisions made to the questionnaire in an iterative process. In the initial 39 item instrument, we identified 7 items where two or more participants reported difficulty. Participants preferred a four-week recall period (compared to a two-week recall period) and response options with a 5-point response scale. The final version of the CHP-HRQOL includes 40 items with a median reading level between 6th and 7th grade.
The CHP-HRQOL instrument demonstrated high content validity and is ready for psychometric testing in further validation studies.
慢性过敏性肺炎（CHP）是由肺部组织在接触吸入性环境抗原刺激物后发生的免疫介导反应所引起。我们之前记录了CHP对患者生活的影响方式，并且现已开发出一种针对该疾病的工具——CHP-健康相关生活质量（HRQOL）工具，用于测量健康相关生活质量（HRQOL）。本研究的目的是评估CHP-HRQOL的内容效度。
对患有CHP的成年人进行认知访谈。在每轮访谈之间对该工具进行修订和完善。获取了关于指导语、条目、回答选项和回忆期的反馈。访谈者标记出参与者在理解、措辞或误解方面有困难的条目，并审查参与者的反馈以进行修订，在适当的时候添加或删除条目。使用弗莱什-金凯德年级水平和易读性分数计算可读性统计数据。
在三轮访谈中对10名参与者进行了访谈，并以迭代的方式对问卷进行了修订。在最初的39个条目的工具中，我们确定了7个条目，有两名或更多参与者报告在这些条目上有困难。参与者更喜欢四周的回忆期（与两周的回忆期相比）以及采用5点回答量表的回答选项。CHP-HRQOL的最终版本包括40个条目，阅读水平中位数在6年级和7年级之间。
CHP-HRQOL工具显示出较高的内容效度，并且准备好在进一步的验证研究中进行心理测量测试。
