Aronson Kerri I, Rajan Mangala, Varadarajan Janani, Paul Tessy K, Swigris Jeffrey J, Krishnan Jamuna K, Kaner Robert J, Martinez Fernando J, Safford Monika M, Pinheiro Laura C
Division of Pulmonary and Critical Care, Weill Cornell Medicine, New York, NY, USA.
Division of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
ERJ Open Res. 2024 Aug 5;10(4). doi: 10.1183/23120541.00155-2024. eCollection 2024 Jul.
Disease-specific health-related quality of life (HRQOL) instruments enable us to capture domains that are most relevant to specific patient populations and are useful when a more individualised approach to patient assessment is desired. In this study, we assessed the validity and reliability of the first instrument specifically developed to measure HRQOL in hypersensitivity pneumonitis (HP).
A 39-item HP-HRQOL instrument and several anchors were collected from a cohort of patients with HP. Exploratory factor analysis and item reduction were utilised to construct a shortened version of the instrument. Several validity and reliability analyses were conducted on this version of the HP-HRQOL.
59 patients with HP completed the study. The revised HP-HRQOL instrument comprises 15 items composing two factors (domains): 1) impacts on daily life; and 2) mental wellbeing. Internal consistency reliability was strong for Factor 1 (Cronbach's α=0.94, 95% CI 0.92-0.96) and Factor 2 (Cronbach's α=0.89, 95% CI 0.85-0.94). Test-retest reliability was strong (ICC 0.94, 95% CI 0.89-0.97). The HP-HRQOL strongly correlated with other validated patient-reported outcome measures and moderately correlated with % predicted forced vital capacity. The HP-HRQOL distinguished between those with different severities of HP as determined by lung function and supplemental oxygen use.
The HP-HRQOL, the first patient-reported outcome instrument specific to adults with HP, possesses strong validity and reliability characteristics for measuring disease-specific HRQOL and distinguishes among patients with different severities of disease.
疾病特异性健康相关生活质量（HRQOL）工具使我们能够获取与特定患者群体最相关的领域，并且在期望采用更个体化的患者评估方法时很有用。在本研究中，我们评估了首个专门为测量过敏性肺炎（HP）患者的HRQOL而开发的工具的有效性和可靠性。
从一组HP患者中收集了一个包含39个条目的HP-HRQOL工具及多个锚定指标。采用探索性因子分析和条目删减来构建该工具的简化版本。对这个版本的HP-HRQOL进行了多项有效性和可靠性分析。
59例HP患者完成了研究。修订后的HP-HRQOL工具包含15个条目，组成两个因子（领域）：1）对日常生活的影响；2）心理健康。因子1（Cronbach's α=0.94，95%CI 0.92-0.96）和因子2（Cronbach's α=0.89，95%CI 0.85-0.94）的内部一致性信度很强。重测信度很强（组内相关系数ICC 0.94，95%CI 0.89-0.97）。HP-HRQOL与其他经过验证的患者报告结局指标高度相关，与预计用力肺活量百分比中度相关。HP-HRQOL能够区分根据肺功能和补充氧气使用情况确定的不同严重程度的HP患者。
HP-HRQOL是首个针对成年HP患者的患者报告结局工具，在测量疾病特异性HRQOL方面具有很强的有效性和可靠性特征，并且能够区分不同疾病严重程度的患者。
