Breast Medicine Service, Solid Tumor Division, Memorial Sloan Kettering Cancer Center.
Department of Supportive Oncology, Levine Cancer Institute.
Oncology (Williston Park). 2021 Jan 11;35(1):35-41. doi: 10.46883/ONC.2021.3501.0035.
Pain is a primary concern among patients with cancer and cancer survivors. Integrative interventions such as acupuncture, massage, and music therapy are effective nonpharmacologic approaches for cancer pain with low cost and minimal adverse events. Patient-reported outcomes (PROs) that have been validated in many clinical and research settings can be used to evaluate pain intensity, associated symptom burden, and quality of life. Clearly defined, reliable PROs can improve patient satisfaction and symptom control. As integrative oncology continues to evolve and expand, cancer-related pain PROs must be standardized to accurately guide clinicians and researchers. Well-validated pain PROs, such as the Brief Pain Inventory, are among the most commonly used for pain intensity assessment. Multiple symptom assessment tools such as the MD Anderson Symptom Inventory, the Memorial Symptom Assessment Scale, the Edmonton Symptom Assessment System, and the Patient-Reported Outcomes-Common Terminology Criteria for Adverse Events measurement system can also capture pain-associated symptom burden. Electronic PROs provide flexibility in collecting and analyzing PRO data. Clinical trials using carefully selected PROs and rigorous statistical analysis plans are fundamental to conducting high-quality integrative oncology research and promoting utilization of effective integrative interventions to improve patient outcomes. In this review, we aim to summarize current, validated PROs specific to cancer-related pain to aid integrative oncology clinicians and researchers in patient care and in study design and implementation.
疼痛是癌症患者和癌症幸存者的主要关注点。针灸、按摩和音乐疗法等综合干预措施是具有成本效益且不良反应极小的有效非药物治疗癌症疼痛的方法。在许多临床和研究环境中得到验证的患者报告结局（PROs）可用于评估疼痛强度、相关症状负担和生活质量。明确界定、可靠的 PROs 可以提高患者满意度和症状控制。随着综合肿瘤学的不断发展和扩大，癌症相关疼痛 PROs 必须标准化，以准确指导临床医生和研究人员。经过充分验证的疼痛 PROs，如简明疼痛量表，是最常用于评估疼痛强度的量表之一。多种症状评估工具，如 MD 安德森症状量表、纪念症状评估量表、埃德蒙顿症状评估系统和患者报告结局-常见不良事件术语标准测量系统，也可以捕捉与疼痛相关的症状负担。电子 PROs 在收集和分析 PRO 数据方面具有灵活性。使用精心选择的 PROs 和严格的统计分析计划进行临床试验是开展高质量综合肿瘤学研究和促进有效综合干预措施应用以改善患者结局的基础。在这篇综述中，我们旨在总结与癌症相关疼痛相关的当前已验证的 PROs，以帮助综合肿瘤学临床医生和研究人员进行患者护理以及研究设计和实施。
