Collet Tinh-Hai, Pataky Zoltan
Service d'endocrinologie, diabétologie, nutrition et éducation thérapeutique du patient, Département de médecine, HUG, 1211 Genève 14.
Rev Med Suisse. 2021 Jan 13;17(720-1):59-62.
The management of obesity comprises lifestyle changes targeting nutrient content, eating behavior and regular physical activity. Medication (orlistat, liraglutide) and bariatric surgery can later be used, but they require a clear indication and a close follow-up. Studies in chronobiology are now exploring the metabolic benefits of intermittent fasting, which restricts food intake and calorie-containing beverages to a certain window of the 24h cycle, or to certain days of the week/month, thus reinstating the alternance between anabolism and catabolism. However, the current scientific evidence is limited by the sample size and duration of the studies. It is therefore too early for a blanket strategy based on intermittent fasting in all patients with metabolic disorders.
肥胖管理包括针对营养成分、饮食行为和定期体育活动的生活方式改变。后期可使用药物(奥利司他、利拉鲁肽)和减肥手术,但这些需要明确的指征和密切随访。时间生物学的研究目前正在探索间歇性禁食的代谢益处,即把食物摄入和含热量饮料限制在24小时周期的特定时间段内,或一周/一个月的特定几天内,从而恢复合成代谢和分解代谢之间的交替。然而,目前的科学证据受研究样本量和持续时间的限制。因此,对所有代谢紊乱患者一概采用基于间歇性禁食的策略还为时过早。