Pro-rim Foundation, Joinville.
Center for Clinical and Epidemiologic Research, Hospital Universitario, University of São Paulo.
Alzheimer Dis Assoc Disord. 2021;35(2):128-134. doi: 10.1097/WAD.0000000000000431.
Inflammation is associated with poor cognitive performance. GlycA is a novel marker of systemic inflammation, but information on GlycA and cognition is scarce. We aimed to evaluate the association between GlycA and cognitive performance in a large sample from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). In this cross-sectional study, participants with GlycA measured at baseline were included. Cognitive function was evaluated using the word list test, the trail-making test, and the semantic and phonemic verbal fluency tests. The association of GlycA with cognitive performance was investigated using linear regression models adjusted for sociodemographic and clinical variables. A total of 4327 participants were analyzed (mean age=51.5±9.0 y old, 54% were female, 60% white). The mean GlycA was 414.9±69.8 µmol/L. Higher GlycA levels were associated with lower global cognitive performance, even after adjustments for confounders and C-reactive protein. Higher GlycA levels were associated with lower performance in language and executive function domains (language: β=-0.005, 95% confidence interval CI=-0.010, -0.001, P=0.01; and executive function: β=-0.005, 95% confidence interval=0.009, -0.001, P=0.02]. GlycA was associated with worse cognitive performance in the ELSA-Brasil study, independent of C-reactive protein levels. GlycA may be a potential biomarker for cognitive impairment.
炎症与认知表现不佳有关。GlycA 是一种新的全身炎症标志物，但关于 GlycA 与认知的信息还很有限。我们旨在评估巴西纵向成人健康研究（ELSA-Brasil）中一个大样本中 GlycA 与认知表现之间的关系。在这项横断面研究中，纳入了基线时测量 GlycA 的参与者。使用单词列表测试、连线测试和语义和语音流畅性测试评估认知功能。使用线性回归模型调整社会人口统计学和临床变量后，研究了 GlycA 与认知表现的相关性。共分析了 4327 名参与者（平均年龄 51.5±9.0 岁，54%为女性，60%为白人）。平均 GlycA 为 414.9±69.8µmol/L。即使在校正混杂因素和 C 反应蛋白后，较高的 GlycA 水平与整体认知表现较差相关。较高的 GlycA 水平与语言和执行功能领域的表现下降相关（语言：β=-0.005，95%置信区间 CI=-0.010，-0.001，P=0.01；执行功能：β=-0.005，95%置信区间=0.009，-0.001，P=0.02]。在 ELSA-Brasil 研究中，GlycA 与认知表现较差相关，独立于 C 反应蛋白水平。GlycA 可能是认知障碍的潜在生物标志物。
