Saari A, Kivisaari L, Standertskjöld-Nordenstam C G, Brackett K, Schröder T
Second Dept. of Surgery, University Central Hospital, Helsinki, Finland.
Scand J Gastroenterol. 1988 Jan;23(1):53-8. doi: 10.3109/00365528809093847.
Twenty-five piglets were subjected to experimental transduodenal pancreatography, using three contrast media (CM), namely sodium meglumine diatrizoate (Urografin), meglumine ioxaglate (Hexabrix), and iohexol (Omnipaque), all diluted to a concentration of 300 mg/ml of iodine. The emptying of CM from pancreatic ducts was studied by repeated roentgenograms, and pancreatic irritation by serum amylase and phospholipase A2 measurements. On the 3rd day after pancreatography the glands were removed for histologic examination of tissue damage. Hyperamylasaemia was seen in 53% of the animals 12 to 15 h after examination, to equal extents in each group. Minimal acinar destruction was seen on histologic examination in all cases. The changes were least when diatrizoate was used. The difference from the changes seen in the ioxaglate group was significant (p less than 0.05). Emptying of CM from the ducts was highly significantly (p less than 0.001) faster in the diatrizoate group than in the other groups. Rapid emptying may be an advantage in clinical endoscopic retrograde pancreaticocholangiography.
25只仔猪接受了实验性经十二指肠胰腺造影术，使用三种造影剂（CM），即葡甲胺泛影酸钠（优维显）、碘克沙葡胺（六复锐）和碘海醇（欧乃派克），均稀释至碘浓度为300mg/ml。通过重复的X线片研究造影剂从胰管的排空情况，并通过测量血清淀粉酶和磷脂酶A2来研究胰腺刺激情况。胰腺造影术后第3天，取出腺体进行组织损伤的组织学检查。检查后12至15小时，53%的动物出现高淀粉酶血症，每组程度相同。所有病例的组织学检查均可见最小程度的腺泡破坏。使用泛影酸盐时变化最小。与碘克沙酸盐组所见变化的差异具有显著性（p<0.05）。泛影酸盐组造影剂从导管的排空速度比其他组快得多（p<0.001）。快速排空在临床内镜逆行胰胆管造影中可能是一个优势。
