Saari A
Second Department of Surgery, University Central Hospital, Helsinki, Finland.
Acta Radiol. 1989 Jan-Feb;30(1):81-6.
Diatrizoate, iohexol and ioxaglate were compared in experimental pancreatography in piglets. Outflow of contrast medium (CM) through the pancreatic papilla was permitted (n = 14) or impaired (n = 17) during examination. The CM concentrations were measured in portal and systemic plasma and in lymph to study the absorption of CM. Absorption of diatrizoate and iohexol was similar in both types of experiment, but radiographically, diatrizoate escaped significantly earlier from the pancreatic duct when outflow was permitted (p less than 0.01), suggesting that the CM was absorbed mainly during injection. Ioxaglate concentrations rose more slowly in systemic plasma and lymph, and fell more slowly in the portal plasma than those of diatrizoate and iohexol, which suggests that ioxaglate was absorbed over a longer period. When outflow was impaired, ioxaglate concentrations remained on a lower level, indicating less penetration in the pancreatic parenchyma. CM absorption varied markedly within each group, suggesting that variations in intraductal pressure and flow are more important in absorption than the type of CM used.
在仔猪实验性胰腺造影中对泛影葡胺、碘海醇和碘克沙醇进行了比较。检查期间，造影剂（CM）通过胰乳头的流出情况分为允许流出（n = 14）或受阻（n = 17）两种。测量门静脉和全身血浆以及淋巴液中的CM浓度以研究CM的吸收情况。在两种类型的实验中，泛影葡胺和碘海醇的吸收情况相似，但在影像学上，当允许流出时，泛影葡胺从胰管中逸出的时间明显更早（p < 0.01），这表明CM主要在注射期间被吸收。碘克沙醇在全身血浆和淋巴液中的浓度上升较慢，在门静脉血浆中的下降也比泛影葡胺和碘海醇慢，这表明碘克沙醇的吸收时间更长。当流出受阻时，碘克沙醇的浓度保持在较低水平，表明其在胰腺实质中的渗透较少。每组内CM的吸收差异显著，这表明导管内压力和流量的变化对吸收的影响比所用CM的类型更为重要。
