Department of Cytopathology, Faculty of Medicine, Ankara University, Ankara, Turkey.
Department of Pathology, Faculty of Medicine, Ankara University, Ankara, Turkey.
Diagn Cytopathol. 2021 Apr;49(4):509-517. doi: 10.1002/dc.24698. Epub 2021 Jan 14.
Milan system for reporting salivary gland cytopathology (MSRSGC) was proposed to provide a standardized reporting system for salivary gland fine needle aspiration biopsies. Modified Menghini type semi-automatic aspiration biopsy needles provide small tissue fragments (STFs), as well as cellular smears, and immunohistochemical and molecular studies can be performed using the STFs.
We aimed to evaluate the contribution of STFs and ancillary techniques to pre-operative diagnosis of salivary gland lesions.
In this study, smears of 287 cases with histopathological correlation were re-reviewed and assigned to one of the MSRSGC categories. In the second step, histopathological and immunohistochemical findings in STFs were evaluated together with cytological findings. Final diagnoses were obtained with the inclusion of flow cytometry (FC) results when available. Risk of malignancy (ROM) was calculated for each diagnostic category.
In the evaluation based on smears, a specific diagnosis could be obtained in 64.8% of the cases. ROMs were 0% for nondiagnostic (ND), 5.6% for non-neoplastic (NN), 55% for atypia of undetermined significance (AUS), 0.6% for benign neoplasm (BN), 27.8% for salivary gland neoplasm of uncertain malignant potential (SUMP), and 100% for suspicious for malignancy (SFM) and malignant (M) categories. With the addition of histopathological and immunohistochemical findings and FC results, a specific diagnosis could be obtained in 75.2% of the cases. ROMs were 0% for ND, 4.5% for NN, 53.8% for AUS, 0.6% for BN, 0% for SUMP, and 100% for SFM/M categories.
STFs contribute correct categorization of salivary gland lesions. The major contribution of ancillary methods is in the SUMP category.
米兰唾液腺细胞病理学报告系统（MSRSGC）旨在为唾液腺细针抽吸活检提供标准化报告系统。改良 Menghini 半自动抽吸活检针提供小组织碎片（STFs），以及细胞涂片，可以使用 STFs 进行免疫组织化学和分子研究。
我们旨在评估 STFs 和辅助技术对唾液腺病变术前诊断的贡献。
在这项研究中，对 287 例具有组织病理学相关性的病例的涂片进行了重新审查，并将其分配到 MSRSGC 中的一个类别。在第二步中，评估了 STFs 中的组织病理学和免疫组织化学发现以及细胞学发现。最终诊断包括在有条件时包括流式细胞术（FC）结果。为每个诊断类别计算了恶性风险（ROM）。
在基于涂片的评估中，64.8%的病例可以获得明确诊断。ROM 为非诊断性（ND）的 0%，非肿瘤性（NN）的 5.6%，意义未确定的非典型性（AUS）的 55%，良性肿瘤（BN）的 0.6%，唾液腺肿瘤恶性潜能不确定（SUMP）的 27.8%，可疑恶性（SFM）和恶性（M）的 100%。通过添加组织病理学和免疫组织化学发现和 FC 结果，75.2%的病例可以获得明确诊断。ROM 为 ND 的 0%，NN 的 4.5%，AUS 的 53.8%，BN 的 0.6%，SUMP 的 0%，SFM/M 的 100%。
STFs 有助于正确分类唾液腺病变。辅助方法的主要贡献在于 SUMP 类别。
