Silberman H, Eisenberg D, Ryan J, Shofler R, Niland J, Kaptein E, Nicoloff J, Spencer C
Department of Surgery, University of Southern California, Los Angeles.
Surg Gynecol Obstet. 1988 Mar;166(3):223-8.
Thyroid indices and nutritional assessment values were measured in 73 critically ill euthyroid patients within 48 hours of admission to the medical or surgical intensive care unit. Significantly increased rates of mortality were observed among patients with decreased T3 or T4 levels or elevated T3UR or rT3 values. Alterations in thyroid function tests were associated with changes in certain putative nutritional indices, including serum albumin and transferrin concentrations, triceps skin fold and skin test reactivity. The data indicated that thyroid parameters measured early in the critical phase of illness are predictive of subsequent outcome. The pathogenesis of altered thyroid hormone metabolism is unknown, but nutritional deprivation may be an important contributing factor.
在73例入住内科或外科重症监护病房48小时内的甲状腺功能正常的危重症患者中，测量了甲状腺指标和营养评估值。T3或T4水平降低或T3UR或反T3值升高的患者死亡率显著增加。甲状腺功能测试的改变与某些假定的营养指标的变化有关，包括血清白蛋白和转铁蛋白浓度、肱三头肌皮褶厚度和皮肤试验反应性。数据表明，在疾病关键期早期测量的甲状腺参数可预测随后的结果。甲状腺激素代谢改变的发病机制尚不清楚，但营养缺乏可能是一个重要的促成因素。
