一台铯-137后装治疗机。低剂量率照射对实验性肿瘤细胞动力学效应的初步结果。
A Cs-137 afterloading device. Preliminary results of cell kinetic effects of low dose-rate irradiation in an experimental tumour.
作者信息
Rutgers D H
机构信息
University Hospital, Department of Radiotherapy, Utrecht, The Netherlands.
出版信息
Strahlenther Onkol. 1988 Feb;164(2):105-7.
A Cs-137 afterloading technique is described which can be used in experimental tumours. Preliminary results, obtained with the human cervical carcinoma ME-180 xenografted to nude athymic mice, demonstrated that 20 Gy of low dose-rate irradiation induced an important redistribution of cells over cell cycle. The proportion of cells in G2-phase increased from 14.4% to 44.2% at 140 hours after irradiation. This method allows an accurate calculation of the dose-rate distribution in the tumour. Investigations of the cell kinetic effects of low dose-rate irradiation, at different dose-rates and different total doses, are therefore facilitated by the technique.
描述了一种可用于实验性肿瘤的铯-137后装技术。用人宫颈癌ME-180接种于裸无胸腺小鼠所获得的初步结果表明，20 Gy的低剂量率照射可引起细胞在细胞周期中的重要重新分布。照射后140小时，G2期细胞比例从14.4%增加到44.2%。该方法可精确计算肿瘤内的剂量率分布。因此，该技术有助于研究不同剂量率和不同总剂量下低剂量率照射的细胞动力学效应。
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