Department of Biochemistry, School of Life Sciences, University of Hyderabad, (PO) Gachibowli, Hyderabad 500046, TS, India.
Department of Biochemistry, School of Life Sciences, University of Hyderabad, (PO) Gachibowli, Hyderabad 500046, TS, India.
Cell Signal. 2021 Apr;80:109924. doi: 10.1016/j.cellsig.2021.109924. Epub 2021 Jan 11.
Toll-like receptors (TLRs) are a class of proteins (patterns recognition receptors-PRRs) capable of recognizing molecules frequently found in pathogens (that are so-called pathogen-associated molecular patterns-PAMPs), they play a key role in the initiation of innate immune response by detecting PAMPs. Our findings show that the functional effects of TLRs co-stimulation on megakaryocytopoiesis. A single cell may receive multiple signal inputs and we consider that multiple TLRs are likely triggered during infection by multiple PAMPs that, in turn, might be involved in infection driven megakaryocytopoiesis, and the present study provide the evidence for the megakaryocytic effects of TLRs co-stimulation.
Toll-like receptors (TLRs) 是一类能够识别病原体中常见分子的蛋白质（模式识别受体-PRRs）（即所谓的病原体相关分子模式-PAMPs），它们在通过检测 PAMPs 来启动先天免疫反应方面发挥着关键作用。我们的研究结果表明，TLRs 共刺激对巨核细胞生成的功能影响。单个细胞可能接收到多个信号输入，我们认为在受到多种 PAMPs 的感染时，可能会触发多个 TLRs，而这反过来又可能参与感染驱动的巨核细胞生成，本研究为 TLRs 共刺激的巨核细胞效应提供了证据。
