Schiffner G, Zywietz F, Lierse W
Anatomisches Institut, Universität Hamburg.
Strahlenther Onkol. 1988 Feb;164(2):94-104.
Cellular effects of a combined treatment with X-rays (15 Gy) and local microwave hyperthermia (43 degrees C, 60 min) on the tumor tissue of the rhabdomyosarcoma R1H of the rat were studied with light and electron microscopy. The results were compared with the cell reactions obtained after X-rays (15 Gy) alone. The histological results and the morphometric data show that the time course of cell damage changes individually with the treatment applied. After radiation alone a cell oedema occurs within some days. After a combined treatment, however, a marked cell oedema and cell lysis is already observed after 24 hours. An intensive shrinking of the cell nuclei is found at day 6th, attended with pyknosis, karyolysis and cell fragments in the extended extracellular area. In comparison with radiation alone the processes of repair and repopulation in the R1H tissue are remarkably delayed after a combined treatment.
采用光镜和电镜研究了X射线（15 Gy）联合局部微波热疗（43℃，60分钟）对大鼠横纹肌肉瘤R1H肿瘤组织的细胞效应。将结果与单独使用X射线（15 Gy）后获得的细胞反应进行比较。组织学结果和形态计量学数据表明，细胞损伤的时间进程随所应用的治疗方法而单独变化。单独放疗后数天内会出现细胞水肿。然而，联合治疗后，24小时后就已观察到明显的细胞水肿和细胞溶解。在第6天发现细胞核强烈收缩，伴有核固缩、核溶解以及细胞碎片出现在扩大的细胞外区域。与单独放疗相比，联合治疗后R1H组织中的修复和再增殖过程明显延迟。
