Zywietz F
Strahlentherapie. 1982 Apr;158(4):255-7.
The response of the rhabdomyosarcoma R1H of the rat was investigated after single doses of X-rays applied alone or in combination with hyperthermia. Tumours of 2.3 cm3 growing in the flank of the animals were locally irradiated with 15 and 30 Gy of 200-kV X-rays and/or heated by microwaves of 2450 MHz with a non-contact applicator. Temperature of the tumours as well as the body of the animals was measured using thermocouples. Heating the tumours at 43 degrees C for various time intervals caused a regrowth delay that increased linearly with treatment time. In combined treatments, hyperthermia was applied 20 minutes after irradiation. The rhabdomyosarcoma R1H showed an enhanced volume regression and tumour growth delay after combined treatment as compared to irradiation alone. After a single dose of 15 Gy, postirradiation treatments at 43 degrees C for 30 and 60 minutes lead to TER values of 1.3 and 1.8, respectively. After combining a dose of 30 Gy with hyperthermia at 43 degrees C (30 or 60 min), the TER values obtained ranged from 1.5 to 1.7.
对单独使用或与热疗联合使用单剂量X射线后的大鼠横纹肌肉瘤R1H的反应进行了研究。在动物胁腹生长的体积为2.3 cm³的肿瘤，用15和30 Gy的200 kV X射线进行局部照射和/或用2450 MHz的微波通过非接触式辐射器加热。使用热电偶测量肿瘤以及动物身体的温度。在43℃下对肿瘤加热不同时间间隔会导致肿瘤再生长延迟，且该延迟随治疗时间呈线性增加。在联合治疗中，热疗在照射后20分钟进行。与单独照射相比，横纹肌肉瘤R1H在联合治疗后显示出体积退缩增强和肿瘤生长延迟。单次给予15 Gy剂量后，在43℃下照射后分别进行30分钟和60分钟的后处理，治疗增益比（TER）值分别为1.3和1.8。将30 Gy剂量与43℃的热疗（30或60分钟）联合后，获得的TER值范围为1.5至1.7。
