Dada Oluwagbenga, Adanty Christopher, Dai Nasia, Jeremian Richie, Alli Sauliha, Gerretsen Philip, Graff Ariel, Strauss John, De Luca Vincenzo
CAMH, Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
CAMH, Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Psychiatry Res. 2021 Feb;296:113646. doi: 10.1016/j.psychres.2020.113646. Epub 2020 Dec 15.
The physiological changes associated with normal aging are known to occur earlier in individuals with schizophrenia (SCZ). One of the phenomena linked with normal aging is the change in patterns of epigenetic modifications. We recruited 138 individuals with SCZ spectrum disorders and extracted DNA from white blood cells. The combinations of pre-selected DNA methylation sites were utilized to estimate the 'methylation age' (DNAm age) and evaluate evidence of epigenetic age acceleration. We investigated the correlation between the epigenetic age acceleration measures and psychosis severity; furthermore, we estimated blood cell counts based on DNA methylation levels. The extrinsic epigenetic age acceleration showed a significant correlation with the Brief Psychiatric Rating Scale (BPRS) disorganization subscale(r=0.222, p=0.039).Both Horvath age acceleration and Hannum age acceleration showed a significant correlation (r=0.221, p=0.029; r=0.242, p=0.017 respectively) with the Symptom Checklist 90 (SCL-90) psychotic domain. Overall, this study shows some evidence of epigenetic age acceleration associated with psychosis severity using two different algorithms for DNAm age analysis.
已知与正常衰老相关的生理变化在精神分裂症（SCZ）患者中出现得更早。与正常衰老相关的现象之一是表观遗传修饰模式的变化。我们招募了138名患有SCZ谱系障碍的个体，并从白细胞中提取了DNA。利用预先选择的DNA甲基化位点组合来估计“甲基化年龄”（DNAm年龄），并评估表观遗传年龄加速的证据。我们研究了表观遗传年龄加速指标与精神病严重程度之间的相关性；此外，我们根据DNA甲基化水平估计血细胞计数。外在表观遗传年龄加速与简明精神病评定量表（BPRS）紊乱分量表显著相关（r=0.222，p=0.039）。Horvath年龄加速和Hannum年龄加速均与症状自评量表90（SCL-90）精神病领域显著相关（分别为r=0.221，p=0.029；r=0.242，p=0.017）。总体而言，本研究使用两种不同的算法进行DNAm年龄分析，显示出一些与精神病严重程度相关的表观遗传年龄加速证据。
