中通量透析膜：它们会对 COVID-19 血液透析患者的结局产生影响吗？
Medium Cut-Off Dialysis Membranes: Can They Have Impact on Outcome of COVID-19 Hemodialysis Patients?
机构信息
Department of Nephrology, Kartal Dr. Lütfi Kırdar City Hospital, Istanbul, Turkey,
Department of Nephrology, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
出版信息
Blood Purif. 2021;50(6):921-924. doi: 10.1159/000513621. Epub 2021 Jan 14.
INTRODUCTION
Severe acute respiratory syndrome coronavirus-2 may lead to high levels of expression of inflammatory cytokines. Medium cut-off (MCO) membranes may make greater clearances for large-middle molecules (including cytokines) than low-flux (LF) membranes. In this study, we aimed to evaluate the impact of MCO membranes on outcome of COVID-19 patients on hemodialysis (HD).
METHODS
Sixty COVID-19 HD patients were included in this study. The patients were categorized into 2 groups regarding type of HD membranes. Clinical data were taken from medical records.
RESULTS
Initial crp and ferritin levels, which are surragates of cytokine storm and severity of disease in COVID-19, were significantly higher in MCO membrane group compared to LF group (p = 0.037 and 0.000, respectively). Although there were more patients with severe disease in MCO group, there were no significant differences regarding need for intensive care unit and death.
CONCLUSION
It may be an option to use MCO membranes in HD patients with COVID-19 in order to reduce cytokine levels and prevent cytokine storm.
简介
严重急性呼吸综合征冠状病毒 2 可能导致炎症细胞因子的高表达。中截留（MCO）膜可能比低通量（LF）膜对大中分子（包括细胞因子）具有更大的清除率。在这项研究中，我们旨在评估 MCO 膜对 COVID-19 血液透析（HD）患者结局的影响。
方法
本研究纳入了 60 名 COVID-19 血液透析患者。根据血液透析膜的类型将患者分为 2 组。临床数据取自病历。
结果
与 LF 组相比，MCO 膜组的初始 CRP 和铁蛋白水平（COVID-19 中细胞因子风暴和疾病严重程度的替代指标）显著升高（p=0.037 和 0.000，分别）。尽管 MCO 组有更多的重症患者，但在需要重症监护和死亡方面无显著差异。
结论
为了降低细胞因子水平并预防细胞因子风暴，在 COVID-19 血液透析患者中使用 MCO 膜可能是一种选择。
Zotero 插件