Ostrowski Nicole, Roy Abhijit, Kumta Prashant N
Swanson School of Engineering, University of Pittsburgh, 815C Benedum Hall, 3700 O'Hara Street, Pittsburgh, Pennsylvania 15261, United States.
ACS Biomater Sci Eng. 2016 Jul 11;2(7):1067-1083. doi: 10.1021/acsbiomaterials.6b00056. Epub 2016 Jun 6.
In the search for more ideal bone graft materials for clinical application, the investigation into ceramic bone cements or bone void filler is ongoing. Calcium phosphate-based materials have been widely explored and implemented for medical use in bone defect repair. Such materials are an excellent choice because the implant mimics the natural chemistry of mineralized bone matrix and in injectable cement form, can be implemented with relative ease. However, of the available calcium phosphate cements, none fully meet the ideal standard, displaying low strengths and acidic setting reactions or slow setting times, and are often very slow to resorb in vivo. The study of magnesium phosphates for bone cements is a relatively new field compared to traditional calcium phosphate bone cements. Although reports are more limited, preliminary studies have shown that magnesium phosphate cements (MPC) may be a strong alternative to calcium phosphates for certain applications. The goal of the present publication is to review the history and achievements of magnesium phosphate-based cements or bone void fillers to date, assess how these cements compare with calcium phosphate competitors and to analyze the future directions and outlook for the research, development, and clinical implementation of these cements.
在寻找更适用于临床的理想骨移植材料的过程中，对陶瓷骨水泥或骨缺损填充剂的研究正在进行。磷酸钙基材料已被广泛探索并应用于骨缺损修复的医学领域。这类材料是绝佳选择，因为植入物模仿矿化骨基质的天然化学组成，且以可注射水泥形式存在，相对易于应用。然而，现有的磷酸钙水泥均未完全达到理想标准，表现出强度低、酸性凝固反应或凝固时间长的问题，并且在体内的吸收通常非常缓慢。与传统的磷酸钙骨水泥相比，磷酸镁骨水泥的研究是一个相对较新的领域。尽管相关报道较少，但初步研究表明，在某些应用中，磷酸镁水泥（MPC）可能是磷酸钙的有力替代品。本出版物的目的是回顾迄今为止磷酸镁基水泥或骨缺损填充剂的历史和成就，评估这些水泥与磷酸钙竞品相比的情况，并分析这些水泥在研究、开发和临床应用方面的未来方向和前景。
