Qi Lei, Zhao Tong, Yan Jinge, Ge Weiwen, Jiang Weidong, Wang Jing, Gholipourmalekabadi Mazaher, Lin Kaili, Wang Xiuhui, Zhang Lei
Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.
Department's Education Deputy, Department of Medical Biotechnology, Iran University of Medical Sciences, Tehran, Iran.
Biomater Transl. 2024 Mar 28;5(1):3-20. doi: 10.12336/biomatertransl.2024.01.002. eCollection 2024.
Reconstruction of bone defects or fractures caused by ageing, trauma and tumour resection is still a great challenge in clinical treatment. Although autologous bone graft is considered as gold standard, the source of natural bone is limited. In recent years, regenerative therapy based on bioactive materials has been proposed for bone reconstruction. Specially, numerous studies have indicated that bioactive ceramics including silicate and phosphate bioceramics exhibit excellent osteoinductivity and osteoconductivity, further promote bone regeneration. In addition, magnesium (Mg) element, as an indispensable mineral element, plays a vital role in promoting bone mineralisation and formation. In this review, different types of Mg-containing bioceramics including Mg-containing calcium phosphate-based bioceramics (such as Mg-hydroxyapatite, Mg-biphasic calcium phosphate), Mg-containing calcium silicate-based bioceramics (such as MgSiO, CaMgSiO and Mg-doped bioglass), Mg-based biocements, Mg-containing metal/polymer-bioceramic composites were systematacially summarised. Additionally, the fabrication technologies and their materiobiological effects were deeply discussed. Clinical applications and perspectives of magnesium-containing bioceramics for bone repair are highlighted. Overall, Mg-containing bioceramics are regarded as regenerative therapy with their optimised performance. Furthermore, more in-depth two-way researches on their performance and structure are essential to satisfy their clinical needs.
对于因衰老、创伤和肿瘤切除导致的骨缺损或骨折的修复，仍然是临床治疗中的一大挑战。尽管自体骨移植被视为金标准，但天然骨的来源有限。近年来，基于生物活性材料的再生疗法已被提出用于骨修复。特别地，大量研究表明，包括硅酸盐和磷酸盐生物陶瓷在内的生物活性陶瓷表现出优异的骨诱导性和骨传导性，可进一步促进骨再生。此外，镁（Mg）元素作为一种不可或缺的矿物元素，在促进骨矿化和形成方面起着至关重要的作用。在本综述中，系统地总结了不同类型的含镁生物陶瓷，包括含镁磷酸钙基生物陶瓷（如镁羟基磷灰石、镁双相磷酸钙）、含镁硅酸钙基生物陶瓷（如MgSiO、CaMgSiO和镁掺杂生物玻璃）、镁基生物水泥、含镁金属/聚合物 - 生物陶瓷复合材料。此外，还深入讨论了其制备技术及其材料生物学效应。重点介绍了含镁生物陶瓷在骨修复中的临床应用和前景。总体而言，含镁生物陶瓷因其优化的性能被视为再生疗法。此外，对其性能和结构进行更深入的双向研究对于满足临床需求至关重要。
