Siddiqui S M, Rao G S, Pandya K P
Industrial Toxicology Research Centre, Lucknow, India.
Toxicology. 1988 Mar;48(3):245-51. doi: 10.1016/0300-483x(88)90105-9.
The effect of a single dose of benzene (0.5 ml/kg body wt i.p.) on the heme saturation of tryptophan pyrrolase activity in liver was examined. There was a significant decrease in the heme saturation of hepatic tryptophan pyrrolase, suggesting depletion of "regulatory heme". After benzene administration there was significant increase in delta-aminolevulinate (ALA) synthetase activity (approx. 2-fold) while delta-aminolevulinate dehydratase activity was significantly decreased, however, ferrochelatase and heme oxygenase activities were unaltered. Administration of tryptophan to benzene pretreated rats showed a reversal of benzene effects on heme synthesizing enzymes: there is an increase in the heme saturation of tryptophan pyrrolase and decrease in delta-aminolevulinate synthetase. However, there was no significant alteration in the activity of delta-aminolevulinate dehydratase.
研究了单次腹腔注射苯（0.5毫升/千克体重）对肝脏中色氨酸吡咯酶活性的血红素饱和度的影响。肝脏色氨酸吡咯酶的血红素饱和度显著降低，表明“调节性血红素”耗竭。给予苯后，δ-氨基乙酰丙酸（ALA）合成酶活性显著增加（约2倍），而δ-氨基乙酰丙酸脱水酶活性显著降低，然而，铁螯合酶和血红素加氧酶活性未改变。给经苯预处理的大鼠注射色氨酸后，苯对血红素合成酶的影响出现逆转：色氨酸吡咯酶的血红素饱和度增加，δ-氨基乙酰丙酸合成酶降低。然而，δ-氨基乙酰丙酸脱水酶的活性没有显著改变。
