乙酸盐、金属阳离子、苯巴比妥、卟啉原及甘氨酸酰基转移酶底物对大鼠肝脏脱辅基（色氨酸吡咯酶）利用血红素的影响。
The effects of acetate, metal cations, phenobarbitone, porphyrogens and substrates of glycine acyltransferase on the utilization of haem by rat liver apo-(tryptophan pyrrolase).
作者信息
Badawy A A
出版信息
Biochem J. 1977 May 15;164(2):431-8. doi: 10.1042/bj1640431.
Abstract
- The utilization of haem by rat liver apo-(tryptophan pyrrolase) under basal conditions and after enhancement of the enzyme activity by various mechanisms was studied under the influence of treatments affecting various aspects of liver haem metabolism. 2. These treatments were: benzoate and p-aminobenzoate as substrates of glycine acyltransferase, acetate as an inhibitor of 5-aminolaevulinate synthase activity, enhancement of 5-aminolaevulinate dehydratase by aluminium, destruction of haem and inhibition of ferrochelatase by porphyrogens, increased haem utilization by phenobarbitone and enhancement of haem oxygenase activity by metal cations. 3. The results show that the haem saturation of the apoenzyme is sensitive to all these treatments. 4. The possible usefulness of tryptophan pyrrolase in studying the regulation of liver haem is suggested.
摘要
- 研究了在影响肝脏血红素代谢各个方面的处理影响下，大鼠肝脏脱辅基（色氨酸吡咯酶）在基础条件下以及通过各种机制增强酶活性后对血红素的利用情况。2. 这些处理包括：苯甲酸和对氨基苯甲酸作为甘氨酸酰基转移酶的底物，乙酸作为5-氨基酮戊酸合酶活性的抑制剂，铝增强5-氨基酮戊酸脱水酶活性，卟啉原破坏血红素并抑制亚铁螯合酶，苯巴比妥增加血红素利用以及金属阳离子增强血红素加氧酶活性。3. 结果表明，脱辅基酶的血红素饱和度对所有这些处理均敏感。4. 提示色氨酸吡咯酶在研究肝脏血红素调节方面可能有用。
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