Venault Antoine, Liou Cheng-Sian, Yeh Lu-Chen, Jhong Jheng-Fong, Huang James, Chang Yung
Department of Chemical Engineering and R&D Center for Membrane Technology, Chung Yuan Christian University, 200 Chung Pei Road, Chung-Li City 32023, Taiwan.
Yeu Ming Tai Chemical Industrial Co. Ltd, Taichung 407, Taiwan.
ACS Biomater Sci Eng. 2017 Dec 11;3(12):3338-3350. doi: 10.1021/acsbiomaterials.7b00732. Epub 2017 Nov 7.
Despite a set of properties ideal to the design of wound dressings, bioinert membranes are seldom applied as wound-healing systems. This work presents a unique series of random copolymers of glycidyl methacrylate (GMA) and poly(ethylene glycol) methacrylate (PEGMA), namely GMA--PEGMA, used to surface-modify by grafting onto method polytetrafluorethylene membranes, with the aim of developing wound dressings for quick and efficient wound closure. It is shown that the membrane modified with G50P50 copolymer combines high surface hydrophilicity, high porosity, protein resistance, bacterial resistance, and hemocompatibility, essential properties to wound dressings. Fibrinogen adsorption was measured to be 11.4 ± 3.9% (compared with virgin membrane) correlating with a low water contact angle (14°), whereas the attachment of fluorescent after 24 h, erythrocytes, leukocytes, thrombocytes, and cells from whole blood was reduced by 85-90%, compared with the virgin membrane. G50P50 membrane was tested as a wound dressing, which outperformed hydrophilic gels of PEGMA in terms of wound-closure kinetic and a commercial dressing in terms of homogeneity of the granulation layer. The facile surface-modification of ePTFE membrane using unique GMA--PEGMA copolymer leads to an antibiofouling porous material with improved hemocompatibility combining numerous essential properties of wound dressings and contributing toward the development of the ideal bandage.
尽管生物惰性膜具有一系列适合伤口敷料设计的特性，但很少被用作伤口愈合系统。这项工作展示了一系列独特的甲基丙烯酸缩水甘油酯（GMA）和聚（乙二醇）甲基丙烯酸酯（PEGMA）的无规共聚物，即GMA-PEGMA，通过接枝法用于对聚四氟乙烯膜进行表面改性，目的是开发用于快速有效伤口闭合的伤口敷料。结果表明，用G50P50共聚物改性的膜兼具高表面亲水性、高孔隙率、抗蛋白质性、抗菌性和血液相容性，这些都是伤口敷料的基本特性。测得纤维蛋白原吸附率为11.4±3.9%（与原始膜相比），这与低水接触角（14°）相关，而与原始膜相比，24小时后荧光标记的红细胞、白细胞、血小板和全血中的细胞附着减少了85-90%。G50P50膜作为伤口敷料进行了测试，在伤口闭合动力学方面优于PEGMA亲水凝胶，在肉芽层均匀性方面优于市售敷料。使用独特的GMA-PEGMA共聚物对ePTFE膜进行简便的表面改性，可得到一种具有改善血液相容性的抗生物污染多孔材料，该材料兼具伤口敷料的多种基本特性，有助于开发理想的绷带。
