Wang Allen Y, Rafalko Joseph, MacDonald Melinda, Ming Xintian, Kocharian Richard
Preclinical Center of Excellence, Johnson & Johnson Medical Devices Companies, Route 22 West, Somerville, New Jersey 08876-0151, United States.
ACS Biomater Sci Eng. 2017 Dec 11;3(12):3675-3686. doi: 10.1021/acsbiomaterials.7b00382. Epub 2017 Nov 17.
Topical absorbable hemostats are routinely utilized in surgical procedures to assist in controlling intraoperative bleeding. SURGICEL Original Absorbable Hemostat, one of the most frequently used adjunctive hemostats, is composed of oxidized regenerated cellulose (ORC). We report here that a novel powdered form of ORC, composed of aggregates of ORC fine fibers, provides additional valuable hemostatic performance characteristics and retains the biochemical and bactericidal profile of the parent ORC fabric. The ORC aggregates are more effective in promoting coagulation than their constituent ORC fine fibers because of more favorable surface energetics and surface area. Aggregates with similar particle size distributions that have higher sphericity values exhibit better coagulation efficacy. Finally, ORC aggregates more effectively promote clot formation than starch-based hemostatic particles. The results of this investigation indicate that the efficacy of this novel powdered hemostat is based on its chemical composition, morphology, and particle surface energetics.
局部可吸收止血剂在外科手术中经常被用于协助控制术中出血。SURGICEL原装可吸收止血剂是最常用的辅助止血剂之一，由氧化再生纤维素（ORC）组成。我们在此报告，一种由ORC细纤维聚集体构成的新型ORC粉末形式具有额外的重要止血性能特征，并保留了母体ORC织物的生化和杀菌特性。由于更有利的表面能和表面积，ORC聚集体在促进凝血方面比其组成的ORC细纤维更有效。具有相似粒度分布且球形度值较高的聚集体表现出更好的凝血效果。最后，ORC聚集体比淀粉基止血颗粒更有效地促进血栓形成。这项研究的结果表明，这种新型粉末止血剂的功效基于其化学成分、形态和颗粒表面能。
