住院水杨酸中毒患者中的循环性休克

Circulatory Shock among Hospitalized Patients for Salicylate Intoxication.

作者信息

Petnak Tananchai, Thongprayoon Charat, Kaewput Wisit, Qureshi Fawad, Boonpheng Boonphiphop, Vallabhajosyula Saraschandra, Bathini Tarun, Mao Michael A, Lertjitbanjong Ploypin, Cheungpasitporn Wisit

机构信息

Division of Pulmonary and Pulmonary Critical Care Medicine, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

出版信息

Diseases. 2021 Jan 12;9(1):7. doi: 10.3390/diseases9010007.

DOI:10.3390/diseases9010007

PMID:33445533

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7839009/

Abstract

BACKGROUND

This study aimed to evaluate the risk factors for circulatory shock and its impact on outcomes in patients hospitalized for salicylate intoxication.

METHODS

We used the National Inpatient Sample to identify patients hospitalized primarily for salicylate intoxication from 2003-2014. Circulatory shock was identified based on hospital diagnosis code for any type of shock or hypotension. We compared clinical characteristics, in-hospital treatments, outcomes, and resource use between patients with and without circulatory shock associated with salicylate intoxication.

RESULTS

Of 13,805 hospital admissions for salicylate intoxication, circulatory shock developed in 484 (4%) admissions. Risk factors for development of circulatory shock included older age, female sex, concurrent psychotropic medication overdose, anemia, congestive heart failure, volume depletion, rhabdomyolysis, seizure, gastrointestinal bleeding, and sepsis. Circulatory shock was significantly associated with increased odds of any organ failure and in-hospital mortality. Length of hospital stay and hospitalization cost was significantly higher in patients with circulatory shock.

CONCLUSION

Approximately 4% of patients admitted for salicylate intoxication developed circulatory shock. Circulatory shock was associated with worse clinical outcomes and increased resource use.

摘要

背景

本研究旨在评估水杨酸盐中毒住院患者循环性休克的危险因素及其对预后的影响。

方法

我们使用全国住院患者样本，确定2003年至2014年主要因水杨酸盐中毒住院的患者。根据任何类型休克或低血压的医院诊断代码确定循环性休克。我们比较了伴有和不伴有与水杨酸盐中毒相关的循环性休克患者的临床特征、住院治疗、预后和资源使用情况。

结果

在13805例因水杨酸盐中毒住院的患者中，484例（4%）出现循环性休克。循环性休克发生的危险因素包括年龄较大、女性、同时存在精神药物过量、贫血、充血性心力衰竭、容量耗竭、横纹肌溶解、癫痫发作、胃肠道出血和脓毒症。循环性休克与任何器官衰竭和住院死亡率增加的几率显著相关。循环性休克患者的住院时间和住院费用显著更高。