Labombarda Fabien, Roule Vincent, Rebouh Idir, Ruscica Massimiliano, Watts Gerald F, Sirtori Cesare R
Department of Cardiology, Centre Hospitalier Universitaire de Caen, 14000 Caen, France.
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
J Clin Med. 2021 Jan 12;10(2):256. doi: 10.3390/jcm10020256.
Risk stratification using non-invasive imaging of the coronary vessels is emerging as an optimal standard of care for patients with dyslipidemias. Of particular interest is the evaluation of the left main coronary artery (LMCA), where calcium deposition appears to be a predictor of cardiovascular events.
In coronary patients, we evaluated wall thickness and internal diameter of the LMCA examined by transthoracic echocardiography (TTE) and compared these with findings obtained by optical frequency domain imaging (OFDI), this latter also used to evaluate calcium deposition.
A significant positive correlation between TTE and OFDI for the anterior wall thickness (r = 0.41, = 0.043) and internal diameter (r = 0.36, = 0.048) of the LMCA was detected. Echocardiographic wall measurements were higher in patients with fibro-calcific plaques. The receiver operating characteristic (ROC) curve showed that an anterior wall thickness of LMCA ≥ 1.4 mm was predictive of fibro-calcific plaque (area under the curve = 0.815 and = 0.006), sensitivity and specificity being 76.9% and 80%, respectively (Youden's Index = 0.56).
Measurement of anterior wall thickness of the LMCA by TTE and OFDI appears to be closely correlated and may predict the presence of coronary calcification.
利用冠状动脉的非侵入性成像进行风险分层正成为血脂异常患者的最佳治疗标准。特别值得关注的是左主干冠状动脉（LMCA）的评估，其中钙沉积似乎是心血管事件的一个预测指标。
在冠心病患者中，我们评估了经胸超声心动图（TTE）检查的LMCA的壁厚度和内径，并将其与光学频域成像（OFDI）获得的结果进行比较，后者也用于评估钙沉积。
检测到TTE与OFDI在LMCA前壁厚度（r = 0.41，P = 0.043）和内径（r = 0.36，P = 0.048）方面存在显著正相关。纤维钙化斑块患者的超声心动图壁测量值更高。受试者工作特征（ROC）曲线显示，LMCA前壁厚度≥1.4 mm可预测纤维钙化斑块（曲线下面积 = 0.815，P = 0.006），敏感性和特异性分别为76.9%和80%（约登指数 = 0.56）。
通过TTE和OFDI测量LMCA前壁厚度似乎密切相关，并且可能预测冠状动脉钙化的存在。
