Rozhl Chir. 2020 Winter;99(11):481-486.
Thyroid cancer is the most common endocrine malignancy, the treatment is multidisciplinary and multimodal. Thyroid tumors are heterogeneous in origin, morphology, biological behavior and therapeutic options. Substantial advances in diagnostic methods for thyroid cancer have led to detection of earlier stages of the disease that have the possibility of targeted therapeutic treatment and improved patient prognosis. In addition to surgical treatment, hormonal suppression and radioiodine therapy, targeted molecular therapy, which requires genetic testing, has come to the fore in recent decades. In the summary, we present an overview of current knowledge on the genetic background of individual types of thyroid carcinomas and the possibilities of therapeuticintervention.
甲状腺癌是最常见的内分泌恶性肿瘤，其治疗是多学科和多模式的。甲状腺肿瘤在起源、形态、生物学行为和治疗选择方面具有异质性。甲状腺癌的诊断方法取得了重大进展，使得能够更早地发现有可能进行靶向治疗和改善患者预后的疾病阶段。除了手术治疗、激素抑制和放射性碘治疗外，靶向分子治疗（需要基因检测）在最近几十年也变得越来越重要。在总结中，我们概述了关于各种类型甲状腺癌的遗传背景的现有知识以及治疗干预的可能性。
