Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Institute of Organ Transplantation, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Nat Prod Res. 2022 Jul;36(14):3544-3552. doi: 10.1080/14786419.2020.1868464. Epub 2021 Jan 15.
One new 3,5-dimethylorsellinic acid (DMOA)-based meroterpenoid (), one prenylated tryptophan derivative (), together with ten known compounds (-) were isolated from the endophytic fungus sp. from . Their structures and absolute configurations were determined by NMR spectroscopic data, HRESIMS data, UV and IR data as well as electronic circular dichroism (ECD) calculation. In structure, compound was a rare example of DMOA-based meroterpenoid with a -fused C/D ring system, and compound possessed an unusual ()-oxime group. In bioactivity, the lovastatin analogues , , and showed potential immunosuppressive activity against anti-CD3/anti-CD28 monoclonal antibodies (mAbs)-irritated murine splenocytes proliferation, with IC values ranging from (5.30 ± 0.51) M to (16.51 ± 1.62) M.
从内生真菌 sp. 中分离得到一种新的 3,5-二甲基奥尔酸（DMOA）- 生源二萜（），一种被侧链戊二烯基化的色氨酸衍生物（），以及另外十个已知化合物（-）。通过 NMR 光谱数据、HRESIMS 数据、UV 和 IR 数据以及电子圆二色性（ECD）计算确定了它们的结构和绝对构型。在结构上，化合物 是一种罕见的基于 DMOA 的生源二萜，具有 - 稠合的 C/D 环系统，而化合物 则具有不寻常的 ()-肟基团。在生物活性方面，洛伐他汀类似物 、 、 和 对抗 CD3/抗 CD28 单克隆抗体（mAbs）刺激的小鼠脾细胞增殖表现出潜在的免疫抑制活性，IC 值范围为（5.30 ± 0.51）M 至（16.51 ± 1.62）M。
