Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, China.
J Asian Nat Prod Res. 2023 Sep;25(9):834-841. doi: 10.1080/10286020.2022.2164490. Epub 2023 Jan 8.
A chemical investigation of 95% ethanol extract from the stem and branch of has resulted in the isolation and characterization of two new compounds, one neolignan () and one phenylalanine derivative (), as well as four known compounds (). The structures of the new compounds were determined based on extensive spectroscopic analyses. The absolute configuration of compound was defined by X-ray crystallographic analyses and electronic circular dichroism calculation. In addition, compounds and exhibited inhibitory effects against NO production in LPS-induced RAW 264.7 macrophages with the IC value ranging from 3.51 μM to 30.40 μM.
从茎和枝的 95%乙醇提取物中进行的化学研究导致分离和表征了两种新化合物，一种新木脂素（）和一种苯丙氨酸衍生物（），以及四种已知化合物（）。根据广泛的光谱分析确定了新化合物的结构。通过 X 射线晶体学分析和电子圆二色性计算确定了化合物的绝对构型。此外，化合物和对 LPS 诱导的 RAW 264.7 巨噬细胞中 NO 产生具有抑制作用，IC 值范围为 3.51 μM 至 30.40 μM。
