Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
Department of Ophthalmology, Health Sciences University, Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
Curr Eye Res. 2021 Aug;46(8):1209-1213. doi: 10.1080/02713683.2021.1877311. Epub 2021 Jan 22.
This study aimed to evaluate the retinal blood vessel parameters and the foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) in patients with acromegaly in comparison with healthy controls.
A total of 45 patients with acromegaly and 45 healthy controls were included in this study. In all patients, the vessel density (VD) of the deep and superficial macular vascular networks and the foveal avascular zone (FAZ) were measured using OCTA. The correlation of insulin-like growth factor 1 (IGF-1) level and disease duration with deep macular VD and FAZ values was analyzed. All parameters were registered. Results were assessed and compared between the two groups.
Deep macular plexus VD values were lower in patients with acromegaly compared to the control group. No significant differences in VD values in the superficial segment, except for that in the inferior parafovea ( = .01) were found between the two groups. Furthermore, patients with acromegaly showed enlargement in the superficial ( = .30) and deep FAZ areas ( < .001). IGF-1 level and disease duration showed a significant negative correlation with the deep whole image ( = -0.216, = .041, = -0.339, = .001, respectively), deep parafovea ( = -0.271, = .01; = -0.372, < .001, respectively), deep parafovea superior hemi ( = -0.342, = .001; = -0.350, = .001, respectively), deep parafovea temporal ( = -0.224, = .034; = -0.234, = .026, respectively), deep parafovea nasal ( = -0.320, = .002; = -0.361, < .001, respectively), and deep parafovea superior VD values ( = -0.293, = .005; = -0.307, = .003, respectively) and a significant positive correlation with the deep FAZ area values ( = 0.244, = .02; = 0.329, = .002, respectively).
VD values in the deep macular capillary plexus were lower in patients with acromegaly, and the superficial and deep FAZ area enlarged. Patients with acromegaly may have an increased risk of developing ocular vascular complications. OCTA can be used to evaluate retinal blood VD in patients with acromegaly.
本研究旨在通过光相干断层扫描血管造影术（OCTA）评估肢端肥大症患者的视网膜血管参数和中心凹无血管区（FAZ）面积，并与健康对照组进行比较。
共纳入 45 例肢端肥大症患者和 45 例健康对照者。对所有患者均采用 OCTA 测量深层和浅层黄斑血管网的血管密度（VD）和中心凹无血管区（FAZ）。分析胰岛素样生长因子 1（IGF-1）水平和疾病持续时间与深层黄斑 VD 和 FAZ 值的相关性。记录所有参数。评估并比较两组之间的结果。
与对照组相比，肢端肥大症患者的深层黄斑丛 VD 值较低。两组间浅层血管段 VD 值无明显差异，但在下象限（ =.01）有差异。此外，肢端肥大症患者的浅层（ =.30）和深层 FAZ 区域扩大（ <.001）。IGF-1 水平和疾病持续时间与深层全像（ = -0.216， =.041， = -0.339， =.001）、深层中央凹旁（ = -0.271， =.01； = -0.372， <.001）、深层中央凹旁上方（ = -0.342， =.001； = -0.350， =.001）、深层中央凹旁颞侧（ = -0.224， =.034； = -0.234， =.026）、深层中央凹旁鼻侧（ = -0.320， =.002； = -0.361， <.001）和深层中央凹旁上方 VD 值（ = -0.293， =.005； = -0.307， =.003）呈显著负相关，与深层 FAZ 面积值呈显著正相关（ = 0.244， =.02； = 0.329， =.002）。
肢端肥大症患者深层黄斑毛细血管丛 VD 值降低，浅层和深层 FAZ 区域扩大。肢端肥大症患者可能有发生眼部血管并发症的风险增加。OCTA 可用于评估肢端肥大症患者的视网膜血管血流密度。
